Details of the Target

General Information of Target

Target ID LDTP03584
Target Name Homeobox protein Hox-A13 (HOXA13)
Gene Name HOXA13
Gene ID 3209
Synonyms
HOX1J; Homeobox protein Hox-A13; Homeobox protein Hox-1J
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTASVLLHPRWIEPTVMFLYDNGGGLVADELNKNMEGAAAAAAAAAAAAAAGAGGGGFPH
PAAAAAGGNFSVAAAAAAAAAAAANQCRNLMAHPAPLAPGAASAYSSAPGEAPPSAAAAA
AAAAAAAAAAAAASSSGGPGPAGPAGAEAAKQCSPCSAAAQSSSGPAALPYGYFGSGYYP
CARMGPHPNAIKSCAQPASAAAAAAFADKYMDTAGPAAEEFSSRAKEFAFYHQGYAAGPY
HHHQPMPGYLDMPVVPGLGGPGESRHEPLGLPMESYQPWALPNGWNGQMYCPKEQAQPPH
LWKSTLPDVVSHPSDASSYRRGRKKRVPYTKVQLKELEREYATNKFITKDKRRRISATTN
LSERQVTIWFQNRRVKEKKVINKLKTTS
Target Type
Literature-reported
Target Bioclass
Transcription factor
Family
Abd-B homeobox family
Subcellular location
Nucleus
Function
Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
TTD ID
T25675
Uniprot ID
P31271
DrugMap ID
TTN26OM
Ensemble ID
ENST00000649031.1
HGNC ID
HGNC:5102

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C194(1.52)  LDD3364  [1]
AHL-Pu-1
 Probe Info  		C291(4.92)  LDD0168  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C291(4.92)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C291(2.97)  LDD0169  [2]
 LDCM0215  AC10 HEK-293T C194(1.20)  LDD1508  [4]
 LDCM0277  AC18 HEK-293T C194(0.98)  LDD1516  [4]
 LDCM0279  AC2 HEK-293T C194(1.15)  LDD1518  [4]
 LDCM0286  AC26 HEK-293T C194(1.04)  LDD1525  [4]
 LDCM0295  AC34 HEK-293T C194(1.06)  LDD1534  [4]
 LDCM0304  AC42 HEK-293T C194(1.17)  LDD1543  [4]
 LDCM0313  AC50 HEK-293T C194(1.15)  LDD1552  [4]
 LDCM0321  AC58 HEK-293T C194(1.17)  LDD1560  [4]
 LDCM0369  CL100 HEK-293T C194(0.97)  LDD1573  [4]
 LDCM0371  CL102 HEK-293T C194(0.93); C291(0.99)  LDD1575  [4]
 LDCM0373  CL104 HEK-293T C194(0.97)  LDD1577  [4]
 LDCM0375  CL106 HEK-293T C194(0.94); C291(0.97)  LDD1579  [4]
 LDCM0377  CL108 HEK-293T C194(1.02)  LDD1581  [4]
 LDCM0380  CL110 HEK-293T C194(0.90); C291(0.91)  LDD1584  [4]
 LDCM0382  CL112 HEK-293T C194(1.00)  LDD1586  [4]
 LDCM0384  CL114 HEK-293T C194(0.86); C291(0.85)  LDD1588  [4]
 LDCM0386  CL116 HEK-293T C194(1.02)  LDD1590  [4]
 LDCM0388  CL118 HEK-293T C194(1.01); C291(1.06)  LDD1592  [4]
 LDCM0391  CL120 HEK-293T C194(1.17)  LDD1595  [4]
 LDCM0393  CL122 HEK-293T C194(1.03); C291(0.91)  LDD1597  [4]
 LDCM0395  CL124 HEK-293T C194(1.10)  LDD1599  [4]
 LDCM0397  CL126 HEK-293T C194(0.95); C291(1.06)  LDD1601  [4]
 LDCM0399  CL128 HEK-293T C194(1.05)  LDD1603  [4]
 LDCM0401  CL14 HEK-293T C194(1.00); C291(0.80)  LDD1605  [4]
 LDCM0403  CL16 HEK-293T C194(1.26)  LDD1607  [4]
 LDCM0405  CL18 HEK-293T C194(1.14)  LDD1609  [4]
 LDCM0407  CL2 HEK-293T C194(1.08); C291(0.78)  LDD1611  [4]
 LDCM0414  CL26 HEK-293T C194(0.97); C291(0.97)  LDD1618  [4]
 LDCM0416  CL28 HEK-293T C194(1.09)  LDD1620  [4]
 LDCM0419  CL30 HEK-293T C194(1.22)  LDD1623  [4]
 LDCM0429  CL4 HEK-293T C194(1.08)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C194(0.93)  LDD1634  [4]
 LDCM0432  CL42 HEK-293T C194(1.13)  LDD1636  [4]
 LDCM0441  CL50 HEK-293T C194(0.96); C291(0.89)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C194(1.09)  LDD1646  [4]
 LDCM0445  CL54 HEK-293T C194(1.05)  LDD1648  [4]
 LDCM0451  CL6 HEK-293T C194(1.13)  LDD1654  [4]
 LDCM0454  CL62 HEK-293T C194(0.91); C291(0.85)  LDD1657  [4]
 LDCM0456  CL64 HEK-293T C194(1.06)  LDD1659  [4]
 LDCM0458  CL66 HEK-293T C194(1.12)  LDD1661  [4]
 LDCM0467  CL74 HEK-293T C194(0.96); C291(1.11)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C194(1.08)  LDD1672  [4]
 LDCM0471  CL78 HEK-293T C194(1.02)  LDD1674  [4]
 LDCM0480  CL86 HEK-293T C194(0.85); C291(0.87)  LDD1683  [4]
 LDCM0482  CL88 HEK-293T C194(1.01)  LDD1685  [4]
 LDCM0485  CL90 HEK-293T C194(1.07)  LDD1688  [4]
 LDCM0493  CL98 HEK-293T C194(0.96); C291(0.67)  LDD1696  [4]
 LDCM0427  Fragment51 HEK-293T C194(0.91); C291(0.99)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C194(1.10)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C194(1.06)  LDD1497  [4]
 LDCM0024  KB05 NCI-N87 C194(1.52)  LDD3364  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402