Details of the Target

General Information of Target

Target ID LDTP03583
Target Name Homeobox protein Hox-A11 (HOXA11)
Gene Name HOXA11
Gene ID 3207
Synonyms
HOX1I; Homeobox protein Hox-A11; Homeobox protein Hox-1I
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDFDERGPCSSNMYLPSCTYYVSGPDFSSLPSFLPQTPSSRPMTYSYSSNLPQVQPVREV
TFREYAIEPATKWHPRGNLAHCYSAEELVHRDCLQAPSAAGVPGDVLAKSSANVYHHPTP
AVSSNFYSTVGRNGVLPQAFDQFFETAYGTPENLASSDYPGDKSAEKGPPAATATSAAAA
AAATGAPATSSSDSGGGGGCRETAAAAEEKERRRRPESSSSPESSSGHTEDKAGGSSGQR
TRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKIN
RDRLQYYSANPLL
Target Type
Literature-reported
Target Bioclass
Transcription factor
Family
Abd-B homeobox family
Subcellular location
Nucleus
Function Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
TTD ID
T56290
Uniprot ID
P31270
DrugMap ID
TTEX4ZA
Ensemble ID
ENST00000006015.4
HGNC ID
HGNC:5101

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C93(3.37)  LDD0169  [1]
DBIA
 Probe Info  		C200(1.87)  LDD0080  [2]
IPM
 Probe Info  		C200(0.00); C93(0.00); C82(0.00)  LDD2156  [3]
VSF
 Probe Info  		C200(0.00); C93(0.00)  LDD0007  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C93(3.37)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C93(1.05)  LDD1507  [6]
 LDCM0270  AC15 HEK-293T C93(1.04)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C93(0.96)  LDD1515  [6]
 LDCM0281  AC21 HEK-293T C82(1.00); C93(0.95)  LDD1520  [6]
 LDCM0283  AC23 HEK-293T C93(1.32)  LDD1522  [6]
 LDCM0285  AC25 HEK-293T C93(1.10)  LDD1524  [6]
 LDCM0289  AC29 HEK-293T C82(1.22); C93(1.66)  LDD1528  [6]
 LDCM0292  AC31 HEK-293T C93(0.96)  LDD1531  [6]
 LDCM0294  AC33 HEK-293T C93(1.16)  LDD1533  [6]
 LDCM0298  AC37 HEK-293T C82(1.12); C93(0.88)  LDD1537  [6]
 LDCM0300  AC39 HEK-293T C93(0.95)  LDD1539  [6]
 LDCM0303  AC41 HEK-293T C93(0.93)  LDD1542  [6]
 LDCM0307  AC45 HEK-293T C82(1.04); C93(1.11)  LDD1546  [6]
 LDCM0309  AC47 HEK-293T C93(1.07)  LDD1548  [6]
 LDCM0311  AC49 HEK-293T C93(1.08)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C82(0.90); C93(1.00)  LDD1551  [6]
 LDCM0316  AC53 HEK-293T C82(1.05); C93(1.07)  LDD1555  [6]
 LDCM0318  AC55 HEK-293T C93(1.05)  LDD1557  [6]
 LDCM0320  AC57 HEK-293T C93(1.04)  LDD1559  [6]
 LDCM0325  AC61 HEK-293T C82(1.20); C93(1.07)  LDD1564  [6]
 LDCM0327  AC63 HEK-293T C93(1.07)  LDD1566  [6]
 LDCM0334  AC7 HEK-293T C93(1.01)  LDD1568  [6]
 LDCM0248  AKOS034007472 HEK-293T C82(0.92); C93(1.11)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C93(1.06)  LDD1570  [6]
 LDCM0371  CL102 HEK-293T C82(1.06)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C82(0.95)  LDD1576  [6]
 LDCM0375  CL106 HEK-293T C82(1.01)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C82(0.92)  LDD1580  [6]
 LDCM0379  CL11 HEK-293T C93(1.21)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C82(0.92)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C82(0.85)  LDD1585  [6]
 LDCM0384  CL114 HEK-293T C82(1.05)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C82(0.86)  LDD1589  [6]
 LDCM0388  CL118 HEK-293T C82(0.97)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C82(1.15)  LDD1593  [6]
 LDCM0393  CL122 HEK-293T C82(0.98)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C82(0.81)  LDD1598  [6]
 LDCM0397  CL126 HEK-293T C82(1.02)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C82(0.82)  LDD1602  [6]
 LDCM0401  CL14 HEK-293T C82(0.89)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C82(0.90)  LDD1606  [6]
 LDCM0404  CL17 HEK-293T C93(1.02)  LDD1608  [6]
 LDCM0407  CL2 HEK-293T C82(0.94)  LDD1611  [6]
 LDCM0409  CL21 HEK-293T C82(1.20); C93(1.56)  LDD1613  [6]
 LDCM0411  CL23 HEK-293T C93(1.37)  LDD1615  [6]
 LDCM0414  CL26 HEK-293T C82(1.08)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C82(0.87)  LDD1619  [6]
 LDCM0417  CL29 HEK-293T C93(1.15)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C82(0.90)  LDD1622  [6]
 LDCM0422  CL33 HEK-293T C82(1.09); C93(0.98)  LDD1626  [6]
 LDCM0424  CL35 HEK-293T C93(1.26)  LDD1628  [6]
 LDCM0428  CL39 HEK-293T C82(0.90)  LDD1632  [6]
 LDCM0431  CL41 HEK-293T C93(1.14)  LDD1635  [6]
 LDCM0435  CL45 HEK-293T C82(1.02); C93(1.14)  LDD1639  [6]
 LDCM0437  CL47 HEK-293T C93(1.25)  LDD1641  [6]
 LDCM0440  CL5 HEK-293T C93(1.11)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C82(0.94)  LDD1645  [6]
 LDCM0444  CL53 HEK-293T C93(1.19)  LDD1647  [6]
 LDCM0448  CL57 HEK-293T C82(1.17); C93(1.05)  LDD1651  [6]
 LDCM0450  CL59 HEK-293T C93(1.24)  LDD1653  [6]
 LDCM0454  CL62 HEK-293T C82(1.00)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C82(0.85)  LDD1658  [6]
 LDCM0457  CL65 HEK-293T C93(0.98)  LDD1660  [6]
 LDCM0461  CL69 HEK-293T C82(1.07); C93(1.16)  LDD1664  [6]
 LDCM0464  CL71 HEK-293T C93(1.18)  LDD1667  [6]
 LDCM0467  CL74 HEK-293T C82(1.03)  LDD1670  [6]
 LDCM0470  CL77 HEK-293T C93(1.10)  LDD1673  [6]
 LDCM0475  CL81 HEK-293T C82(1.13); C93(0.97)  LDD1678  [6]
 LDCM0477  CL83 HEK-293T C93(1.01)  LDD1680  [6]
 LDCM0480  CL86 HEK-293T C82(1.01)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C82(1.01)  LDD1684  [6]
 LDCM0483  CL89 HEK-293T C93(1.00)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C82(1.05); C93(1.09)  LDD1687  [6]
 LDCM0488  CL93 HEK-293T C82(1.23); C93(0.92)  LDD1691  [6]
 LDCM0490  CL95 HEK-293T C93(1.35)  LDD1693  [6]
 LDCM0493  CL98 HEK-293T C82(1.16)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C82(0.89)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C82(0.91)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C82(1.00)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C82(0.96)  LDD1631  [6]
 LDCM0022  KB02 HCT 116 C200(1.87)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C200(1.14)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C200(1.36)  LDD0082  [2]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402