Details of the Target

General Information of Target

Target ID LDTP03524
Target Name T-cell differentiation antigen CD6 (CD6)
Gene Name CD6
Gene ID 923
Synonyms
T-cell differentiation antigen CD6; T12; TP120; CD antigen CD6) [Cleaved into: Soluble CD6]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWLFFGITGLLTAALSGHPSPAPPDQLNTSSAESELWEPGERLPVRLTNGSSSCSGTVEV
RLEASWEPACGALWDSRAAEAVCRALGCGGAEAASQLAPPTPELPPPPAAGNTSVAANAT
LAGAPALLCSGAEWRLCEVVEHACRSDGRRARVTCAENRALRLVDGGGACAGRVEMLEHG
EWGSVCDDTWDLEDAHVVCRQLGCGWAVQALPGLHFTPGRGPIHRDQVNCSGAEAYLWDC
PGLPGQHYCGHKEDAGAVCSEHQSWRLTGGADRCEGQVEVHFRGVWNTVCDSEWYPSEAK
VLCQSLGCGTAVERPKGLPHSLSGRMYYSCNGEELTLSNCSWRFNNSNLCSQSLAARVLC
SASRSLHNLSTPEVPASVQTVTIESSVTVKIENKESRELMLLIPSIVLGILLLGSLIFIA
FILLRIKGKYALPVMVNHQHLPTTIPAGSNSYQPVPITIPKEVFMLPIQVQAPPPEDSDS
GSDSDYEHYDFSAQPPVALTTFYNSQRHRVTDEEVQQSRFQMPPLEEGLEELHASHIPTA
NPGHCITDPPSLGPQYHPRSNSESSTSSGEDYCNSPKSKLPPWNPQVFSSERSSFLEQPP
NLELAGTQPAFSAGPPADDSSSTSSGEWYQNFQPPPQPPSEEQFGCPGSPSPQPDSTDND
DYDDISAA
Target Type
Clinical trial
Target Bioclass
Enzyme
Subcellular location
Secreted; Cell membrane
Function
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 . Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as a costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.
TTD ID
T49736
Uniprot ID
P30203
DrugMap ID
TTMF6KC
Ensemble ID
ENST00000313421.11
HGNC ID
HGNC:1691
ChEMBL ID
CHEMBL3712853

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.P456S .
EFO27 SNV: p.G213S .
HLF SNV: p.K252E .
J82 SNV: p.F216L .
JURKAT SNV: p.S292N; p.P582L .
MFE319 SNV: p.E514K; p.S518N .
NCIH2286 Deletion: p.V60CfsTer56 .
TGBC1TKB SNV: p.G131A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C155(5.52)  LDD0204  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0102  BDHI 8 Jurkat C155(5.52)  LDD0204  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0625  F8 Ramos C155(1.27)  LDD2187  [6]
 LDCM0572  Fragment10 Ramos C155(1.74)  LDD2189  [6]
 LDCM0573  Fragment11 Ramos C155(1.16)  LDD2190  [6]
 LDCM0574  Fragment12 Ramos C155(1.38)  LDD2191  [6]
 LDCM0575  Fragment13 Ramos C155(0.80)  LDD2192  [6]
 LDCM0576  Fragment14 Ramos C155(0.77)  LDD2193  [6]
 LDCM0579  Fragment20 Ramos C155(1.12)  LDD2194  [6]
 LDCM0580  Fragment21 Ramos C155(1.12)  LDD2195  [6]
 LDCM0582  Fragment23 Ramos C155(0.98)  LDD2196  [6]
 LDCM0578  Fragment27 Ramos C155(0.87)  LDD2197  [6]
 LDCM0586  Fragment28 Ramos C155(0.77)  LDD2198  [6]
 LDCM0588  Fragment30 Ramos C155(0.92)  LDD2199  [6]
 LDCM0589  Fragment31 Ramos C155(0.93)  LDD2200  [6]
 LDCM0468  Fragment33 Ramos C155(1.16)  LDD2202  [6]
 LDCM0596  Fragment38 Ramos C155(1.13)  LDD2203  [6]
 LDCM0566  Fragment4 Ramos C155(1.29)  LDD2184  [6]
 LDCM0610  Fragment52 Ramos C155(1.23)  LDD2204  [6]
 LDCM0614  Fragment56 Ramos C155(1.72)  LDD2205  [6]
 LDCM0022  KB02 HEK-293T C155(0.85)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C155(0.88)  LDD1497  [7]
 LDCM0024  KB05 U-937 C170(1.71)  LDD3482  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
T-cell differentiation antigen CD6 (CD6) . P30203
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Galectin-3 (LGALS3) . P17931
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CD166 antigen (ALCAM) . Q13740
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Galectin-1 (LGALS1) . P09382
Lymphocyte cytosolic protein 2 (LCP2) . Q13094

The Drug(s) Related To This Target

Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Itolizumab Antibody D06QSN

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840