Details of the Target

General Information of Target

Target ID LDTP03375
Target Name Hepatocyte growth factor-like protein (MST1)
Gene Name MST1
Gene ID 4485
Synonyms
D3F15S2; DNF15S2; HGFL; Hepatocyte growth factor-like protein; Macrophage stimulatory protein; Macrophage-stimulating protein; MSP) [Cleaved into: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGWLPLLLLLTQCLGVPGQRSPLNDFQVLRGTELQHLLHAVVPGPWQEDVADAEECAGRC
GPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLFQKKDYVRTCIMNNGVGYRG
TMATTVGGLPCQAWSHKFPNDHKYTPTLRNGLEENFCRNPDGDPGGPWCYTTDPAVRFQS
CGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYC
RNPDGSERPWCYTTDPQIEREFCDLPRCGSEAQPRQEATTVSCFRGKGEGYRGTANTTTA
GVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFTLRPGMRAAFCYQIRR
CTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCR
NPDGDSHGPWCYTMDPRTPFDYCALRRCADDQPPSILDPPDQVQFEKCGKRVDRLDQRRS
KLRVVGGHPGNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSSCHMPLTGYEVWLGT
LFQNPQHGEPSLQRVPVAKMVCGPSGSQLVLLKLERSVTLNQRVALICLPPEWYVVPPGT
KCEIAGWGETKGTGNDTVLNVALLNVISNQECNIKHRGRVRESEMCTEGLLAPVGACEGD
YGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVMRLG
Target Bioclass
Enzyme
Family
Peptidase S1 family, Plasminogen subfamily
Subcellular location
Secreted
Uniprot ID
P26927
HGNC ID
HGNC:7380
ChEMBL ID
CHEMBL6042

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C507(0.89)  LDD0814  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DFG-out-4
 Probe Info  		4.60  LDD0075  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HEK-293T C507(0.89)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C507(0.93)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C507(1.39)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C507(1.13)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C507(0.89)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C507(0.83)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C507(1.07)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C507(0.92)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C507(0.95)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C507(1.01)  LDD0823  [1]
 LDCM0227  AC110 HEK-293T C507(1.37)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C507(1.21)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C507(1.37)  LDD0827  [1]
 LDCM0276  AC17 HEK-293T C507(1.34)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C507(1.27)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C507(1.18)  LDD0876  [1]
 LDCM0280  AC20 HEK-293T C507(1.16)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C507(1.44)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C507(1.39)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C507(1.36)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C507(1.25)  LDD0882  [1]
 LDCM0285  AC25 HEK-293T C507(0.77)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C507(0.96)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C507(0.84)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C507(0.74)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C507(0.95)  LDD0887  [1]
 LDCM0291  AC30 HEK-293T C507(0.89)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C507(1.00)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C507(0.78)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C507(0.90)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C507(0.92)  LDD0893  [1]
 LDCM0349  AC83 HEK-293T C507(1.33)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C507(1.40)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C507(0.96)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C507(1.58)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C507(1.66)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C507(1.35)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C507(1.26)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C507(1.08)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C507(1.52)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C507(1.16)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C507(1.36)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C507(1.31)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C507(1.60)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C507(1.74)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C507(2.07)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C507(0.96)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C507(1.10)  LDD0964  [1]
 LDCM0374  CL105 HEK-293T C507(1.06)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C507(1.23)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C507(1.15)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C507(1.16)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C507(1.08)  LDD0976  [1]
 LDCM0380  CL110 HEK-293T C507(1.10)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C507(1.00)  LDD0979  [1]
 LDCM0382  CL112 HEK-293T C507(1.01)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C507(0.69)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C507(0.86)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C507(0.95)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C507(0.94)  LDD0984  [1]
 LDCM0017  DFG-out-2 A431 4.60  LDD0075  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase STK11 (STK11) CAMK Ser/Thr protein kinase family Q15831
Macrophage-stimulating protein receptor (MST1R) Tyr protein kinase family Q04912
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vesicle transport protein SFT2A (SFT2D1) SFT2 family Q8WV19

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Affinity-based probes based on type II kinase inhibitors. J Am Chem Soc. 2012 Nov 21;134(46):19017-25. doi: 10.1021/ja306035v. Epub 2012 Nov 6.