Details of the Target

General Information of Target

Target ID LDTP03345
Target Name Pentraxin-related protein PTX3 (PTX3)
Gene Name PTX3
Gene ID 5806
Synonyms
TNFAIP5; TSG14; Pentraxin-related protein PTX3; Pentaxin-related protein PTX3; Tumor necrosis factor alpha-induced protein 5; TNF alpha-induced protein 5; Tumor necrosis factor-inducible gene 14 protein; TSG-14
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHLLAILFCALWSAVLAENSDDYDLMYVNLDNEIDNGLHPTEDPTPCACGQEHSEWDKLF
IMLENSQMRERMLLQATDDVLRGELQRLREELGRLAESLARPCAPGAPAEARLTSALDEL
LQATRDAGRRLARMEGAEAQRPEEAGRALAAVLEELRQTRADLHAVQGWAARSWLPAGCE
TAILFPMRSKKIFGSVHPVRPMRLESFSACIWVKATDVLNKTILFSYGTKRNPYEIQLYL
SYQSIVFVVGGEENKLVAEAMVSLGRWTHLCGTWNSEEGLTSLWVNGELAATTVEMATGH
IVPEGGILQIGQEKNGCCVGGGFDETLAFSGRLTGFNIWDSVLSNEEIRETGGAESCHIR
GNIVGWGVTEIQPHGGAQYVS
Target Bioclass
Other
Subcellular location
Secreted
Function Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.
Uniprot ID
P26022
Ensemble ID
ENST00000295927.4
HGNC ID
HGNC:9692

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C103(1.33)  LDD1700  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C103(0.61)  LDD2142  [1]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C103(1.04)  LDD2117  [1]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C103(1.11)  LDD2103  [1]
 LDCM0545  Acetamide MDA-MB-231 C103(0.34)  LDD2138  [1]
 LDCM0498  BS-3668 MDA-MB-231 C103(0.53)  LDD2091  [1]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C103(1.31)  LDD2102  [1]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C103(0.46)  LDD2121  [1]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C103(0.43)  LDD2089  [1]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C103(1.39)  LDD2090  [1]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C103(0.74)  LDD2099  [1]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C103(0.32)  LDD2100  [1]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C103(0.99)  LDD2101  [1]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C103(0.54)  LDD2104  [1]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C103(1.29)  LDD2105  [1]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C103(0.65)  LDD2108  [1]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C103(0.91)  LDD2109  [1]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C103(0.60)  LDD2110  [1]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C103(0.54)  LDD2114  [1]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C103(0.51)  LDD2115  [1]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C103(1.77)  LDD2120  [1]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C103(0.79)  LDD2123  [1]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C103(0.44)  LDD2134  [1]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C103(1.33)  LDD1700  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C103(0.62)  LDD2140  [1]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C103(0.84)  LDD2141  [1]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C103(1.35)  LDD2145  [1]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C103(0.86)  LDD2146  [1]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C103(0.51)  LDD2148  [1]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C103(0.58)  LDD2150  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6) . P98066
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor 2 (FGF2) Heparin-binding growth factors family P09038
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ficolin-1 (FCN1) Ficolin lectin family O00602
Ficolin-2 (FCN2) Ficolin lectin family Q15485
Complement factor H (CFH) . P08603
Complement factor H-related protein 1 (CFHR1) . Q03591
Pentraxin-related protein PTX3 (PTX3) . P26022

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264