Details of the Target

General Information of Target

Target ID LDTP03194
Target Name Granulysin (GNLY)
Gene Name GNLY
Gene ID 10578
Synonyms
LAG2; NKG5; TLA519; Granulysin; Lymphokine LAG-2; Protein NKG5; T-cell activation protein 519
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATWALLLLAAMLLGNPGLVFSRLSPEYYDLARAHLRDEEKSCPCLAQEGPQGDLLTKTQ
ELGRDYRTCLTIVQKLKKMVDKPTQRSVSNAATRVCRTGRSRWRDVCRNFMRRYQSRVTQ
GLVAGETAQQICEDLRLCIPSTGPL
Target Bioclass
Transporter and channel
Subcellular location
Secreted
Function
Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.
Uniprot ID
P22749
Ensemble ID
ENST00000263863.9
HGNC ID
HGNC:4414

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KMCH1 SNV: p.Q129Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C43, C45, C46(10.70)  LDD0528  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0201  EV-3 T cell C43, C45, C46(10.70)  LDD0528  [1]
 LDCM0022  KB02 T cell C43(14.28); C45(0.00); C46(0.00)  LDD1703  [1]
 LDCM0024  KB05 T cell C43, C45, C46(20.00)  LDD1709  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 1 (BCL2L1) Bcl-2 family Q07817
Derlin-3 (DERL3) Derlin family Q96Q80

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
3-(N-morpholino)Propanesulfonic Acid . DB03434

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.