Details of the Target

General Information of Target

Target ID LDTP03149
Target Name Bone morphogenetic protein 6 (BMP6)
Gene Name BMP6
Gene ID 654
Synonyms
VGR; Bone morphogenetic protein 6; BMP-6; VG-1-related protein; VG-1-R; VGR-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGLGRRAQWLCWWWGLLCSCCGPPPLRPPLPAAAAAAAGGQLLGDGGSPGRTEQPPPSP
QSSSGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLP
RGEPPPGRLKSAPLFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAH
PLNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKF
NLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWA
SEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMV
AFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVS
FQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAP
TKLNAISVLYFDDNSNVILKKYRNMVVRACGCH
Target Type
Clinical trial
Target Bioclass
Other
Family
TGF-beta family
Subcellular location
Secreted
Function
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression.
TTD ID
T10762
Uniprot ID
P22004
DrugMap ID
TT07RIB
Ensemble ID
ENST00000283147.7
HGNC ID
HGNC:1073
ChEMBL ID
CHEMBL3286078

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C262(0.94)  LDD1508  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C262(0.94)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C262(0.96)  LDD1509  [1]
 LDCM0270  AC15 HEK-293T C262(0.98)  LDD1513  [1]
 LDCM0277  AC18 HEK-293T C262(0.94)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C262(0.89)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C262(0.89)  LDD1518  [1]
 LDCM0283  AC23 HEK-293T C262(1.01)  LDD1522  [1]
 LDCM0286  AC26 HEK-293T C262(0.91)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C262(1.11)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C262(1.06)  LDD1529  [1]
 LDCM0292  AC31 HEK-293T C262(1.10)  LDD1531  [1]
 LDCM0295  AC34 HEK-293T C262(0.94)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C262(1.01)  LDD1535  [1]
 LDCM0300  AC39 HEK-293T C262(1.07)  LDD1539  [1]
 LDCM0304  AC42 HEK-293T C262(1.01)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C262(0.99)  LDD1544  [1]
 LDCM0309  AC47 HEK-293T C262(1.06)  LDD1548  [1]
 LDCM0313  AC50 HEK-293T C262(1.03)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C262(1.19)  LDD1553  [1]
 LDCM0318  AC55 HEK-293T C262(0.94)  LDD1557  [1]
 LDCM0321  AC58 HEK-293T C262(1.00)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C262(1.15)  LDD1561  [1]
 LDCM0327  AC63 HEK-293T C262(1.05)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C262(1.00)  LDD1568  [1]
 LDCM0369  CL100 HEK-293T C262(0.95)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C262(0.90)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C262(0.96)  LDD1581  [1]
 LDCM0379  CL11 HEK-293T C262(1.59)  LDD1583  [1]
 LDCM0382  CL112 HEK-293T C262(0.85)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C262(1.21)  LDD1590  [1]
 LDCM0391  CL120 HEK-293T C262(0.97)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C262(0.85)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C262(1.07)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C262(0.98)  LDD1607  [1]
 LDCM0405  CL18 HEK-293T C262(1.15)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C262(1.21)  LDD1610  [1]
 LDCM0411  CL23 HEK-293T C262(1.55)  LDD1615  [1]
 LDCM0416  CL28 HEK-293T C262(0.86)  LDD1620  [1]
 LDCM0419  CL30 HEK-293T C262(1.01)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C262(1.21)  LDD1624  [1]
 LDCM0424  CL35 HEK-293T C262(1.83)  LDD1628  [1]
 LDCM0429  CL4 HEK-293T C262(0.91)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C262(0.91)  LDD1634  [1]
 LDCM0432  CL42 HEK-293T C262(1.17)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C262(1.16)  LDD1637  [1]
 LDCM0437  CL47 HEK-293T C262(1.34)  LDD1641  [1]
 LDCM0443  CL52 HEK-293T C262(1.14)  LDD1646  [1]
 LDCM0445  CL54 HEK-293T C262(0.93)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C262(1.26)  LDD1649  [1]
 LDCM0450  CL59 HEK-293T C262(1.46)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C262(1.01)  LDD1654  [1]
 LDCM0456  CL64 HEK-293T C262(0.98)  LDD1659  [1]
 LDCM0458  CL66 HEK-293T C262(1.03)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C262(1.19)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C262(1.24)  LDD1665  [1]
 LDCM0464  CL71 HEK-293T C262(1.34)  LDD1667  [1]
 LDCM0469  CL76 HEK-293T C262(1.19)  LDD1672  [1]
 LDCM0471  CL78 HEK-293T C262(1.12)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C262(1.04)  LDD1675  [1]
 LDCM0477  CL83 HEK-293T C262(1.38)  LDD1680  [1]
 LDCM0482  CL88 HEK-293T C262(1.05)  LDD1685  [1]
 LDCM0485  CL90 HEK-293T C262(0.92)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C262(1.09)  LDD1689  [1]
 LDCM0490  CL95 HEK-293T C262(1.18)  LDD1693  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402