Details of the Target

General Information of Target

Target ID LDTP03023
Target Name Thymidine phosphorylase (TYMP)
Gene Name TYMP
Gene ID 1890
Synonyms
ECGF1; Thymidine phosphorylase; TP; EC 2.4.2.4; Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ
Target Type
Successful
Target Bioclass
Enzyme
Family
Thymidine/pyrimidine-nucleoside phosphorylase family
Function
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
TTD ID
T59929
Uniprot ID
P19971
DrugMap ID
TTO0IB8
Ensemble ID
ENST00000252029.8
HGNC ID
HGNC:3148
ChEMBL ID
CHEMBL3106

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C361(5.08)  LDD3311  [1]
IA-alkyne
 Probe Info  		C361(0.00); C280(0.00); C136(0.00)  LDD0162  [2]
TFBX
 Probe Info  		N.A.  LDD0027  [3]
Acrolein
 Probe Info  		N.A.  LDD0217  [4]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]
MPP-AC
 Probe Info  		N.A.  LDD0428  [5]
TPP-AC
 Probe Info  		N.A.  LDD0427  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0107  IAA HeLa N.A.  LDD0221  [4]
 LDCM0022  KB02 22RV1 C361(2.48)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C361(7.06)  LDD2660  [1]
 LDCM0024  KB05 G361 C361(5.08)  LDD3311  [1]
 LDCM0109  NEM HeLa C361(0.00); H402(0.00)  LDD0224  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
LRP chaperone MESD (MESD) MESD family Q14696
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

The Drug(s) Related To This Target

Approved
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Capecitabine Small molecular drug DB01101
Cidofovir Small molecular drug DB00369
Floxuridine Small molecular drug DB00322
Fluorouracil Small molecular drug DB00544
Trifluridine Small molecular drug DB00432
Uridine Small molecular drug D0Y7DP
Tipiracil . DB09343
Investigative
Click To Hide/Show 24 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-(Cyclohexyl)Methyl-5'-o-tritylinosine Small molecular drug D03ITH
1-(Cyclopropyl)Methyl-5'-o-tritylinosine Small molecular drug D04OWX
1-allyl-5'-o-tritylinosine Small molecular drug D06BMN
1-benzyl-5'-o-tritylinosine Small molecular drug D0W6LJ
1-propyl-5'-o-tritylinosine Small molecular drug D05OUP
2'-aminoimidazolylmethyluracils Small molecular drug D0CQ1J
5-benzyl-6-chloropyrimidine-2,4(1h,3h)-dione Small molecular drug D09TBA
5-bromo-6-(Cyclopropylamino)Uracil Hydrochloride Small molecular drug D0Y5UF
5-bromo-6-hydrazinouracil Hydrochloride Small molecular drug D00PMF
5-butyl-6-chloropyrimidine-2,4(1h,3h)-dione Small molecular drug D0RE9X
5-chloro-6-hydrazinouracil Hydrochloride Small molecular drug D0G1DS
5-fluoro-6-[(2-aminoimidazol-1-yl)Methyl]Uracil Small molecular drug D01DAQ
6-amino-5-bromouracil Small molecular drug D0X5RA
6-amino-5-chlorouracil Hydrochloride Small molecular drug D0VW6H
6-bromo-5-phenylpyrimidine-2,4(1h,3h)-dione Small molecular drug D0I7IF
6-chloro-5-(2-thienyl)Pyrimidine-2,4(1h,3h)-dione Small molecular drug D0C0HN
6-chloro-5-heptylpyrimidine-2,4(1h,3h)-dione Small molecular drug D03IMY
6-chloro-5-hexylpyrimidine-2,4(1h,3h)-dione Small molecular drug D0CO5S
6-chloro-5-pentylpyrimidine-2,4(1h,3h)-dione Small molecular drug D0E7SH
6-chloro-5-phenylpyrimidine-2,4(1h,3h)-dione Small molecular drug D01IGW
6-chloro-5-propylpyrimidine-2,4(1h,3h)-dione Small molecular drug D0DX8A
6-fluoro-5-phenylpyrimidine-2,4(1h,3h)-dione Small molecular drug D0E9PL
Tezacitabine Small molecular drug DB06433
Thymine Small molecular drug D0F4KL

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.