Details of the Target

General Information of Target

Target ID LDTP02881
Target Name Zinc finger and SCAN domain-containing protein 20 (ZSCAN20)
Gene Name ZSCAN20
Gene ID 7579
Synonyms
KOX29; ZNF31; ZNF360; Zinc finger and SCAN domain-containing protein 20; Zinc finger protein 31; Zinc finger protein 360; Zinc finger protein KOX29
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAMALELQAQASPQPEPEELLIVKLEEDSWGSESKLWEKDRGSVSGPEASRQRFRQFQYR
DAAGPHEAFSQLWALCCRWLRPEIRLKEQILELLVLEQFLTILPREVQTWVQARHPESGE
EAVALVEDWHRETRTAGQSGLELHTEETRPLKTGEEAQSFQLQPVDPWPEGQSQKKGVKN
TCPDLPNHLNAEVAPQPLKESAVLTPRVPTLPKMGSVGDWEVTAESQEALGPGKHAEKEL
CKDPPGDDCGNSVCLGVPVSKPSNTSEKEQGPEFWGLSLINSGKRSTADYSLDNEPAQAL
TWRDSRAWEEQYQWDVEDMKVSGVHWGYEETKTFLAILSESPFSEKLRTCHQNRQVYRAI
AEQLRARGFLRTLEQCRYRVKNLLRNYRKAKSSHPPGTCPFYEELEALVRARTAIRATDG
PGEAVALPRLGYSDAEMDEQEEGGWDPEEMAEDCNGAGLVNVESTQGPRIAGAPALFQSR
IAGVHWGYEETKAFLAILSESPFSEKLRTCHQNSQVYRAIAERLCALGFLRTLEQCRYRF
KNLLRSYRKAKSSHPPGTCPFYEELDSLMRARAAVRAMGTVREAAGLPRCGQSSAETDAQ
EAWGEVANEDAVKPSTLCPKAPDMGFEMRHEDEDQISEQDIFEGLPGALSKCPTEAVCQP
LDWGEDSENENEDEGQWGNPSQEQWQESSSEEDLEKLIDHQGLYLAEKPYKCDTCMKSFS
RSSHFIAHQRIHTGEKPYKCLECGKNFSDRSNLNTHQRIHTGEKPYKCLECGKSFSDHSN
LITHQRIHTGEKPYKCGECWKSFNQSSNLLKHQRIHLGGNPDQCSEPGGNFAQSPSFSAH
WRNSTEETAPEQPQSISKDLNSPGPHSTNSGEKLYECSECGRSFSKSSALISHQRIHTGE
KPYECAECGKSFSKSSTLANHQRTHTGEKPYKCVDCGKCFSERSKLITHQRVHTGEKPYK
CLECGKFFRDRSNLITHQRIHTGEKPYKCRECGKCFNQSSSLIIHQRIHTGEKPYKCTEC
GKDFNNSSHFSAHRRTHAGGKAS
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
P17040
Ensemble ID
ENST00000361328.7
HGNC ID
HGNC:13093

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.P245S .
CORL88 SNV: p.R548L .
DU145 SNV: p.G829E .
ICC137 SNV: p.S1000P .
ICC3 SNV: p.T783S .
IGROV1 SNV: p.A361T .
MCAS SNV: p.E1019G .
MOLM16 SNV: p.S885F .
MOLT4 SNV: p.A521S .
RVH421 SNV: p.P986S .
SHP77 SNV: p.E798D .
SNU308 SNV: p.N542S DBIA    Probe Info 
SW756 SNV: p.Q813Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C350(1.67)  LDD3325  [1]
HHS-465
 Probe Info  		K736(0.00); K739(0.00); K929(0.00); K932(0.00)  LDD2240  [2]
HHS-475
 Probe Info  		Y959(0.65)  LDD2238  [3]
HHS-482
 Probe Info  		Y931(0.87)  LDD2239  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C525(0.99)  LDD1508  [4]
 LDCM0237  AC12 HEK-293T C559(0.90); C525(1.23)  LDD1510  [4]
 LDCM0270  AC15 HEK-293T C525(0.86)  LDD1513  [4]
 LDCM0277  AC18 HEK-293T C525(1.11)  LDD1516  [4]
 LDCM0279  AC2 HEK-293T C525(1.28)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C559(1.11); C525(1.42)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C525(1.07)  LDD1520  [4]
 LDCM0283  AC23 HEK-293T C525(0.86)  LDD1522  [4]
 LDCM0286  AC26 HEK-293T C525(1.09)  LDD1525  [4]
 LDCM0288  AC28 HEK-293T C559(1.19); C525(1.23)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C525(1.02)  LDD1528  [4]
 LDCM0292  AC31 HEK-293T C525(1.05)  LDD1531  [4]
 LDCM0295  AC34 HEK-293T C525(1.22)  LDD1534  [4]
 LDCM0297  AC36 HEK-293T C559(0.96); C525(0.89)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C525(1.04)  LDD1537  [4]
 LDCM0300  AC39 HEK-293T C525(1.11)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C559(1.06); C525(1.08)  LDD1540  [4]
 LDCM0304  AC42 HEK-293T C525(1.10)  LDD1543  [4]
 LDCM0306  AC44 HEK-293T C559(1.07); C525(1.01)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C525(1.06)  LDD1546  [4]
 LDCM0309  AC47 HEK-293T C525(1.22)  LDD1548  [4]
 LDCM0312  AC5 HEK-293T C525(1.12)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C525(1.05)  LDD1552  [4]
 LDCM0315  AC52 HEK-293T C559(1.22); C525(1.23)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C525(0.81)  LDD1555  [4]
 LDCM0318  AC55 HEK-293T C525(1.04)  LDD1557  [4]
 LDCM0321  AC58 HEK-293T C525(1.06)  LDD1560  [4]
 LDCM0324  AC60 HEK-293T C559(1.16); C525(0.98)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C525(1.29)  LDD1564  [4]
 LDCM0327  AC63 HEK-293T C525(0.77)  LDD1566  [4]
 LDCM0334  AC7 HEK-293T C525(0.88)  LDD1568  [4]
 LDCM0248  AKOS034007472 HEK-293T C525(1.00)  LDD1511  [4]
 LDCM0367  CL1 HEK-293T C559(1.09); C525(1.01)  LDD1571  [4]
 LDCM0370  CL101 HEK-293T C559(0.93); C525(1.11)  LDD1574  [4]
 LDCM0374  CL105 HEK-293T C559(1.42); C525(0.78)  LDD1578  [4]
 LDCM0378  CL109 HEK-293T C559(0.84); C525(0.90)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C525(0.58)  LDD1583  [4]
 LDCM0383  CL113 HEK-293T C559(0.88); C525(0.97)  LDD1587  [4]
 LDCM0387  CL117 HEK-293T C559(0.87); C525(1.01)  LDD1591  [4]
 LDCM0392  CL121 HEK-293T C559(0.98); C525(1.19)  LDD1596  [4]
 LDCM0396  CL125 HEK-293T C559(0.75); C525(1.16)  LDD1600  [4]
 LDCM0400  CL13 HEK-293T C559(1.24); C525(1.29)  LDD1604  [4]
 LDCM0405  CL18 HEK-293T C525(0.95)  LDD1609  [4]
 LDCM0408  CL20 HEK-293T C559(0.96); C525(0.99)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C525(0.84)  LDD1613  [4]
 LDCM0411  CL23 HEK-293T C525(0.96)  LDD1615  [4]
 LDCM0413  CL25 HEK-293T C559(0.96); C525(1.10)  LDD1617  [4]
 LDCM0419  CL30 HEK-293T C525(1.13)  LDD1623  [4]
 LDCM0421  CL32 HEK-293T C559(1.00); C525(0.93)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C525(1.09)  LDD1626  [4]
 LDCM0424  CL35 HEK-293T C525(0.84)  LDD1628  [4]
 LDCM0426  CL37 HEK-293T C559(1.10); C525(0.88)  LDD1630  [4]
 LDCM0432  CL42 HEK-293T C525(0.80)  LDD1636  [4]
 LDCM0434  CL44 HEK-293T C559(0.82); C525(0.98)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C525(0.96)  LDD1639  [4]
 LDCM0437  CL47 HEK-293T C525(0.78)  LDD1641  [4]
 LDCM0439  CL49 HEK-293T C559(1.22); C525(1.15)  LDD1643  [4]
 LDCM0445  CL54 HEK-293T C525(1.23)  LDD1648  [4]
 LDCM0447  CL56 HEK-293T C559(1.14); C525(1.39)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C525(1.05)  LDD1651  [4]
 LDCM0450  CL59 HEK-293T C525(0.97)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C525(0.69)  LDD1654  [4]
 LDCM0453  CL61 HEK-293T C559(0.80); C525(1.11)  LDD1656  [4]
 LDCM0458  CL66 HEK-293T C525(1.63)  LDD1661  [4]
 LDCM0460  CL68 HEK-293T C559(1.39); C525(1.22)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C525(1.13)  LDD1664  [4]
 LDCM0464  CL71 HEK-293T C525(0.89)  LDD1667  [4]
 LDCM0466  CL73 HEK-293T C559(0.78); C525(1.00)  LDD1669  [4]
 LDCM0471  CL78 HEK-293T C525(0.91)  LDD1674  [4]
 LDCM0473  CL8 HEK-293T C559(1.72); C525(1.58)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C559(0.23); C525(0.90)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C525(0.80)  LDD1678  [4]
 LDCM0477  CL83 HEK-293T C525(0.66)  LDD1680  [4]
 LDCM0479  CL85 HEK-293T C559(0.64); C525(1.52)  LDD1682  [4]
 LDCM0484  CL9 HEK-293T C525(0.89)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C525(2.11)  LDD1688  [4]
 LDCM0487  CL92 HEK-293T C559(0.81); C525(0.85)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C525(0.97)  LDD1691  [4]
 LDCM0490  CL95 HEK-293T C525(0.88)  LDD1693  [4]
 LDCM0492  CL97 HEK-293T C559(1.13); C525(1.12)  LDD1695  [4]
 LDCM0022  KB02 EFO-27 C525(1.60)  LDD2322  [1]
 LDCM0023  KB03 HEC-1 C525(5.19)  LDD2767  [1]
 LDCM0024  KB05 UACC257 C350(1.67)  LDD3325  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402