Details of the Target

General Information of Target

Target ID LDTP02755
Target Name Protein C-ets-1 (ETS1)
Gene Name ETS1
Gene ID 2113
Synonyms
EWSR2; Protein C-ets-1; p54
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKAAVDLKPTLTIIKTEKVDLELFPSPDMECADVPLLTPSSKEMMSQALKATFSGFTKEQ
QRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDFQKFCMNGAALCALGKDCFLELAPDF
VGDILWEHLEILQKEDVKPYQVNGVNPAYPESRYTSDYFISYGIEHAQCVPPSEFSEPSF
ITESYQTLHPISSEELLSLKYENDYPSVILRDPLQTDTLQNDYFAIKQEVVTPDNMCMGR
TSRGKLGGQDSFESIESYDSCDRLTQSWSSQSSFNSLQRVPSYDSFDSEDYPAALPNHKP
KGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDG
WEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQS
LLGYTPEELHAMLDVKPDADE
Target Type
Literature-reported
Target Bioclass
Transcription factor
Family
ETS family
Subcellular location
Nucleus
Function
Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.; [Isoform Ets-1 p27]: Acts as a dominant-negative for isoform c-ETS-1A.
TTD ID
T38983
Uniprot ID
P14921
DrugMap ID
TTTGPSD
Ensemble ID
ENST00000319397.7
HGNC ID
HGNC:3488

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.71  LDD0403  [1]
AHL-Pu-1
 Probe Info  		C237(2.03)  LDD0171  [2]
DBIA
 Probe Info  		C237(109.57)  LDD0209  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C416(0.00); C261(0.00); C350(0.00); C31(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C416(0.00); C350(0.00)  LDD0036  [4]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [5]
Lodoacetamide azide
 Probe Info  		C112(0.00); C416(0.00); C350(0.00); C99(0.00)  LDD0037  [4]
NAIA_4
 Probe Info  		C31(0.00); 0.00  LDD2226  [6]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
Compound 11
 Probe Info  		N.A.  LDD2213  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C237(2.03)  LDD0171  [2]
 LDCM0156  Aniline NCI-H1299 11.71  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C112(1.56); C99(1.48)  LDD2214  [8]
 LDCM0625  F8 Ramos C31(1.11)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C31(0.83)  LDD2189  [9]
 LDCM0573  Fragment11 Ramos C31(8.23)  LDD2190  [9]
 LDCM0574  Fragment12 Ramos C31(0.89)  LDD2191  [9]
 LDCM0575  Fragment13 Ramos C31(0.98)  LDD2192  [9]
 LDCM0579  Fragment20 Ramos C31(1.20)  LDD2194  [9]
 LDCM0580  Fragment21 Ramos C31(0.58)  LDD2195  [9]
 LDCM0582  Fragment23 Ramos C31(0.65)  LDD2196  [9]
 LDCM0578  Fragment27 Ramos C31(0.88)  LDD2197  [9]
 LDCM0586  Fragment28 Ramos C31(0.34)  LDD2198  [9]
 LDCM0588  Fragment30 Ramos C31(0.81)  LDD2199  [9]
 LDCM0589  Fragment31 Ramos C31(0.83)  LDD2200  [9]
 LDCM0590  Fragment32 Ramos C31(0.75)  LDD2201  [9]
 LDCM0468  Fragment33 Ramos C31(0.94)  LDD2202  [9]
 LDCM0596  Fragment38 Ramos C31(0.45)  LDD2203  [9]
 LDCM0566  Fragment4 Ramos C31(1.00)  LDD2184  [9]
 LDCM0610  Fragment52 Ramos C31(1.18)  LDD2204  [9]
 LDCM0614  Fragment56 Ramos C31(1.15)  LDD2205  [9]
 LDCM0569  Fragment7 Ramos C31(1.71)  LDD2186  [9]
 LDCM0571  Fragment9 Ramos C31(1.09)  LDD2188  [9]
 LDCM0022  KB02 T cell-activated C416(5.76)  LDD1708  [10]
 LDCM0023  KB03 Jurkat C237(109.57)  LDD0209  [3]
 LDCM0024  KB05 OCUG-1 C31(1.26)  LDD3373  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase COP1 (COP1) COP1 family Q8NHY2
DNA-dependent protein kinase catalytic subunit (PRKDC) PI3/PI4-kinase family P78527
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Eukaryotic translation initiation factor 5B (EIF5B) . O60841
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor Jun (JUN) BZIP family P05412
Protein C-ets-1 (ETS1) ETS family P14921
Homeobox protein Meis1 (MEIS1) TALE/MEIS homeobox family O00470
AT-rich interactive domain-containing protein 4B (ARID4B) . Q4LE39
Forkhead box protein O1 (FOXO1) . Q12778
Nuclear autoantigen Sp-100 (SP100) . P23497
T-cell acute lymphocytic leukemia protein 1 (TAL1) . P17542
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid beta precursor like protein 2 (APLP2) APP family Q06481
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
Serine/arginine-rich splicing factor 11 (SRSF11) Splicing factor SR family Q05519

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
10 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840