Details of the Target

General Information of Target

Target ID LDTP02280
Target Name Pleckstrin (PLEK)
Gene Name PLEK
Gene ID 5341
Synonyms
P47; Pleckstrin; Platelet 47 kDa protein; p47
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPKRIREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQ
DFGKRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIEGGQKFARKSTRRSIRL
PETIDLGALYLSMKDTEKGIKELNLEKDKKIFNHCFTGNCVIDWLVSNQSVRNRQEGLMI
ASSLLNEGYLQPAGDMSKSAVDGTAENPFLDNPDAFYYFPDSGFFCEENSSDDDVILKEE
FRGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSV
ESNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMASRTGK
Target Bioclass
Other
Function Major protein kinase C substrate of platelets.
Uniprot ID
P08567
Ensemble ID
ENST00000234313.8
HGNC ID
HGNC:9070
ChEMBL ID
CHEMBL4523171

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C102(1.01)  LDD3333  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C102(1.99); C59(2.34); C295(0.97)  LDD2187  [4]
 LDCM0572  Fragment10 Ramos C102(0.70); C59(0.58); C295(0.61)  LDD2189  [4]
 LDCM0573  Fragment11 Ramos C102(0.58); C59(0.60); C295(6.32)  LDD2190  [4]
 LDCM0574  Fragment12 Ramos C102(0.89); C59(0.77); C295(0.66)  LDD2191  [4]
 LDCM0575  Fragment13 Ramos C102(1.31); C59(0.95); C295(1.14)  LDD2192  [4]
 LDCM0576  Fragment14 Ramos C102(0.56); C59(0.94); C295(1.01)  LDD2193  [4]
 LDCM0579  Fragment20 Ramos C102(0.74); C59(0.55); C295(0.52)  LDD2194  [4]
 LDCM0580  Fragment21 Ramos C102(0.99); C59(1.10); C295(1.16)  LDD2195  [4]
 LDCM0582  Fragment23 Ramos C102(1.10); C59(1.37); C295(1.50)  LDD2196  [4]
 LDCM0578  Fragment27 Ramos C102(1.11); C59(1.15); C295(1.09)  LDD2197  [4]
 LDCM0586  Fragment28 Ramos C102(0.43); C59(0.51); C295(0.79)  LDD2198  [4]
 LDCM0588  Fragment30 Ramos C102(2.13); C59(1.52); C295(1.22)  LDD2199  [4]
 LDCM0589  Fragment31 Ramos C102(2.09); C59(1.52); C295(1.26)  LDD2200  [4]
 LDCM0590  Fragment32 Ramos C102(0.81); C59(0.76); C295(0.67)  LDD2201  [4]
 LDCM0468  Fragment33 Ramos C102(1.88); C59(1.05); C295(1.07)  LDD2202  [4]
 LDCM0596  Fragment38 Ramos C102(1.51); C59(0.90); C295(1.14)  LDD2203  [4]
 LDCM0566  Fragment4 Ramos C102(0.88); C59(0.76); C295(0.70)  LDD2184  [4]
 LDCM0610  Fragment52 Ramos C102(2.14); C59(1.50); C295(1.22)  LDD2204  [4]
 LDCM0614  Fragment56 Ramos C102(3.78); C59(1.63); C295(1.38)  LDD2205  [4]
 LDCM0569  Fragment7 Ramos C102(0.46); C59(0.52); C295(0.52)  LDD2186  [4]
 LDCM0571  Fragment9 Ramos C102(0.62); C59(0.54); C295(0.61)  LDD2188  [4]
 LDCM0022  KB02 Ramos C102(0.49); C59(0.59); C295(0.51)  LDD2182  [4]
 LDCM0023  KB03 Ramos C102(0.54); C59(0.68); C295(0.74)  LDD2183  [4]
 LDCM0024  KB05 MOLM-13 C102(1.01)  LDD3333  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inositol polyphosphate-5-phosphatase A (INPP5A) Inositol 1,4,5-trisphosphate 5-phosphatase type I family Q14642
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caveolae-associated protein 2 (CAVIN2) CAVIN family O95810

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
4 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578