Details of the Target

General Information of Target

Target ID LDTP01519
Target Name Vesicle-associated membrane protein 5 (VAMP5)
Gene Name VAMP5
Gene ID 10791
Synonyms
Vesicle-associated membrane protein 5; VAMP-5; Myobrevin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGIELERCQQQANEVTEIMRNNFGKVLERGVKLAELQQRSDQLLDMSSTFNKTTQNLAQ
KKCWENIRYRICVGLVVVGVLLIILIVLLVVFLPQSSDSSSAPRTQDAGIASGPGN
Target Bioclass
Other
Family
Synaptobrevin family
Subcellular location
Cell membrane
Function May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.
Uniprot ID
O95183
Ensemble ID
ENST00000306384.5
HGNC ID
HGNC:12646

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C9(0.94)  LDD0078  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 PaTu 8988t C9(2.43)  LDD1094  [1]
 LDCM0226  AC11 PaTu 8988t C9(1.93)  LDD1105  [1]
 LDCM0230  AC113 PaTu 8988t C9(1.04)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C9(1.34)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C9(1.05)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C9(1.42)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C9(1.18)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C9(1.31)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C9(1.04)  LDD1115  [1]
 LDCM0237  AC12 PaTu 8988t C9(0.82)  LDD1116  [1]
 LDCM0238  AC120 PaTu 8988t C9(1.15)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C9(1.36)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C9(1.00)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C9(0.96)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C9(1.63)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C9(1.06)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C9(1.11)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C9(1.41)  LDD1124  [1]
 LDCM0246  AC128 PaTu 8988t C9(1.55)  LDD1125  [1]
 LDCM0247  AC129 PaTu 8988t C9(1.18)  LDD1126  [1]
 LDCM0249  AC130 PaTu 8988t C9(1.26)  LDD1128  [1]
 LDCM0250  AC131 PaTu 8988t C9(1.09)  LDD1129  [1]
 LDCM0251  AC132 PaTu 8988t C9(1.02)  LDD1130  [1]
 LDCM0252  AC133 PaTu 8988t C9(1.06)  LDD1131  [1]
 LDCM0253  AC134 PaTu 8988t C9(0.89)  LDD1132  [1]
 LDCM0254  AC135 PaTu 8988t C9(1.46)  LDD1133  [1]
 LDCM0255  AC136 PaTu 8988t C9(1.39)  LDD1134  [1]
 LDCM0256  AC137 PaTu 8988t C9(1.63)  LDD1135  [1]
 LDCM0257  AC138 PaTu 8988t C9(0.98)  LDD1136  [1]
 LDCM0258  AC139 PaTu 8988t C9(1.17)  LDD1137  [1]
 LDCM0259  AC14 PaTu 8988t C9(1.41)  LDD1138  [1]
 LDCM0260  AC140 PaTu 8988t C9(1.32)  LDD1139  [1]
 LDCM0261  AC141 PaTu 8988t C9(1.15)  LDD1140  [1]
 LDCM0262  AC142 PaTu 8988t C9(0.97)  LDD1141  [1]
 LDCM0270  AC15 PaTu 8988t C9(1.11)  LDD1149  [1]
 LDCM0323  AC6 PaTu 8988t C9(1.75)  LDD1202  [1]
 LDCM0332  AC68 PaTu 8988t C9(0.99)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C9(1.66)  LDD1212  [1]
 LDCM0334  AC7 PaTu 8988t C9(1.10)  LDD1213  [1]
 LDCM0335  AC70 PaTu 8988t C9(1.24)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C9(1.41)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C9(0.85)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C9(0.79)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C9(0.97)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C9(1.12)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C9(1.46)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C9(1.19)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C9(0.83)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C9(0.89)  LDD1223  [1]
 LDCM0345  AC8 PaTu 8988t C9(1.49)  LDD1224  [1]
 LDCM0346  AC80 PaTu 8988t C9(0.96)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C9(1.38)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C9(1.19)  LDD1227  [1]
 LDCM0349  AC83 PaTu 8988t C9(0.86)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C9(0.97)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C9(1.11)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C9(1.01)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C9(0.88)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C9(0.68)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C9(0.67)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C9(0.98)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C9(0.92)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C9(0.89)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C9(0.70)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C9(0.77)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C9(0.80)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C9(0.90)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C9(0.85)  LDD1243  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C9(1.73)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C9(1.45)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C9(1.56)  LDD1154  [1]
 LDCM0020  ARS-1620 HCC44 C9(0.94)  LDD0078  [1]
 LDCM0370  CL101 PaTu 8988t C9(1.24)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C9(1.52)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C9(1.89)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C9(1.29)  LDD1252  [1]
 LDCM0022  KB02 COR-L23 C9(1.61)  LDD2310  [2]
 LDCM0023  KB03 A2780 C9(1.84)  LDD2671  [2]
 LDCM0024  KB05 NCI-H1299 C9(1.76)  LDD3343  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylserine lipase ABHD16A (ABHD16A) ABHD16 family O95870
Catechol O-methyltransferase (COMT) Cation-dependent O-methyltransferase family P21964
Palmitoyltransferase ZDHHC15 (ZDHHC15) DHHC palmitoyltransferase family Q96MV8
Very long chain fatty acid elongase 4 (ELOVL4) ELO family Q9GZR5
NADH-cytochrome b5 reductase 3 (CYB5R3) Flavoprotein pyridine nucleotide cytochrome reductase family P00387
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) HIBADH-related family P31937
Signal peptidase complex catalytic subunit SEC11C (SEC11C) Peptidase S26B family Q9BY50
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Transporter and channel
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Claudin-5 (CLDN5) Claudin family O00501
Claudin-7 (CLDN7) Claudin family O95471
Gap junction alpha-8 protein (GJA8) Connexin family P48165
Syncytin-2 (ERVFRD-1) Gamma type-C retroviral envelope protein family P60508
Transmembrane 4 L6 family member 18 (TM4SF18) L6 tetraspanin family Q96CE8
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Pannexin-1 (PANX1) Pannexin family Q96RD7
Syntaxin-1A (STX1A) Syntaxin family Q16623
Syntaxin-4 (STX4) Syntaxin family Q12846
Syntaxin-5 (STX5) Syntaxin family Q13190
Leukocyte surface antigen CD53 (CD53) Tetraspanin (TM4SF) family P19397
Transmembrane protein 106C (TMEM106C) TMEM106 family Q9BVX2
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Urea transporter 2 (SLC14A2) Urea transporter family Q15849
Sortilin (SORT1) VPS10-related sortilin family Q99523
Exportin-2 (CSE1L) XPO2/CSE1 family P55060
Zinc transporter ZIP2 (SLC39A2) ZIP transporter (TC 2.A.5) family Q9NP94
Renin receptor (ATP6AP2) . O75787
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transmembrane protein 139 (TMEM139) . Q8IV31
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Taste receptor type 2 member 5 (TAS2R5) G-protein coupled receptor T2R family Q9NYW4
Immunoglobulin
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Immunoglobulin superfamily P43628
Killer cell immunoglobulin-like receptor 3DL3 (KIR3DL3) Immunoglobulin superfamily Q8N743
Poliovirus receptor (PVR) Nectin family P15151
V-set and immunoglobulin domain-containing protein 4 (VSIG4) . Q9Y279
Cytokine and receptor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-7 receptor subunit alpha (IL7R) Type I cytokine receptor family P16871
Interleukin-3 receptor subunit alpha (IL3RA) Type I cytokine receptor family P26951
Interleukin-10 receptor subunit alpha (IL10RA) Type II cytokine receptor family Q13651
Other
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
RAB6-interacting golgin (GORAB) GORAB family Q5T7V8
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Synaptosomal-associated protein 29 (SNAP29) SNAP-25 family O95721
Syntaxin-16 (STX16) Syntaxin family O14662
Syntaxin-1B (STX1B) Syntaxin family P61266
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
Transmembrane and coiled-coil domain-containing protein 5A (TMCO5A) TMCO5 family Q8N6Q1
Transmembrane protein 45B (TMEM45B) TMEM45 family Q96B21
Bcl-2-interacting killer (BIK) . Q13323
Fibronectin type III domain-containing protein 9 (FNDC9) . Q8TBE3
Galectin-3-binding protein (LGALS3BP) . Q08380
GRAM domain-containing protein 2B (GRAMD2B) . Q96HH9
Leucine-rich repeat-containing protein 25 (LRRC25) . Q8N386
NKG2-A/NKG2-B type II integral membrane protein (KLRC1) . P26715
Transmembrane protein 52B (TMEM52B) . Q4KMG9

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840