Details of the Target

General Information of Target

Target ID LDTP01270
Target Name Chorion-specific transcription factor GCMb (GCM2)
Gene Name GCM2
Gene ID 9247
Synonyms
GCMB; Chorion-specific transcription factor GCMb; hGCMb; GCM motif protein 2; Glial cells missing homolog 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPAAAVQEAVGVCSYGMQLSWDINDPQMPQELALFDQFREWPDGYVRFIYSSDEKKAQRH
LSGWAMRNTNNHNGHILKKSCLGVVVCTQACTLPDGSRLQLRPAICDKARLKQQKKACPN
CHSALELIPCRGHSGYPVTNFWRLDGNAIFFQAKGVHDHPRPESKSETEARRSAIKRQMA
SFYQPQKKRIRESEAEENQDSSGHFSNIPPLENPEDFDIVTETSFPIPGQPCPSFPKSDV
YKATCDLATFQGDKMPPFQKYSSPRIYLPRPPCSYELANPGYTNSSPYPTLYKDSTSIPN
DTDWVHLNTLQCNVNSYSSYERSFDFTNKQHGWKPALGKPSLVERTNHGQFQAMATRPYY
NPELPCRYLTTPPPGAPALQTVITTTTKVSYQAYQPPAMKYSDSVREVKSLSSCNYAPED
TGMSVYPEPWGPPVTVTRAASPSGPPPMKIAGDCRAIRPTVAIPHEPVSSRTDEAETWDV
CLSGLGSAVSYSDRVGPFFTYNNEDF
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development.
Uniprot ID
O75603
Ensemble ID
ENST00000379491.5
HGNC ID
HGNC:4198

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C454(2.83)  LDD3392  [1]
BTD
 Probe Info  		C454(1.08)  LDD2093  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0520  AKOS000195272 MDA-MB-231 C454(0.63)  LDD2113  [2]
 LDCM0022  KB02 A101D C454(2.18)  LDD2250  [1]
 LDCM0023  KB03 A101D C454(2.13)  LDD2667  [1]
 LDCM0024  KB05 PANC-1 C454(2.83)  LDD3392  [1]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C454(1.08)  LDD2093  [2]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C454(0.89)  LDD2097  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C454(0.67)  LDD2101  [2]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C454(0.41)  LDD2115  [2]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C454(0.58)  LDD2133  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C454(0.64)  LDD2134  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C454(0.97)  LDD2135  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C454(0.40)  LDD2148  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 (JMJD7) . P0C870
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Heat shock transcription factor, Y-linked (HSFY1; HSFY2) HSF family Q96LI6
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Homeobox protein goosecoid-2 (GSC2) Paired homeobox family O15499
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Paired box protein Pax-8 (PAX8) . Q06710
T-box transcription factor TBX19 (TBX19) . O60806
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) CEA family P40199
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 7-1 (KRTAP7-1) KRTAP type 7 family Q8IUC3
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Myozenin-3 (MYOZ3) Myozenin family Q8TDC0
AP-4 complex accessory subunit RUSC1 (RUSC1) . Q9BVN2
Extracellular matrix protein 1 (ECM1) . Q16610
Four and a half LIM domains protein 3 (FHL3) . Q13643
Heat shock factor 2-binding protein (HSF2BP) . O75031
Puratrophin-1 (PLEKHG4) . Q58EX7
RNA-binding protein with multiple splicing (RBPMS) . Q93062
Single-stranded DNA-binding protein, mitochondrial (SSBP1) . Q04837
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060