Details of the Target

General Information of Target

Target ID LDTP01020
Target Name LIM homeobox transcription factor 1-beta (LMX1B)
Gene Name LMX1B
Gene ID 4010
Synonyms
LIM homeobox transcription factor 1-beta; LIM/homeobox protein 1.2; LMX-1.2; LIM/homeobox protein LMX1B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDIATGPESLERCFPRGQTDCAKMLDGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQ
RPISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCME
KIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKEGQLLCKGDYEKEKDLLSSVS
PDESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEV
SSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQEVLSS
RMEGMMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTPPQMPGDHMNPYGNDSIFHDID
SDTSLTSLSDCFLGSSDVGSLQARVGNPIDRLYSMQSSYFAS
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Transcription factor involved in the regulation of podocyte-expressed genes. Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.
Uniprot ID
O60663
Ensemble ID
ENST00000355497.10
HGNC ID
HGNC:6654

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R261C .
CCK81 SNV: p.A278V .
HCC15 SNV: p.S189R .
HT115 SNV: p.F141L .
LS123 SNV: p.C103Ter .
MCC26 SNV: p.G17V .
MEWO SNV: p.S184F .
NUGC3 SNV: p.K114E .
PF382 SNV: p.R223Q .
RKO SNV: p.R16H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C165(1.50)  LDD3401  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C165(1.01)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C165(1.02)  LDD1512  [3]
 LDCM0280  AC20 HEK-293T C165(0.94)  LDD1519  [3]
 LDCM0282  AC22 HEK-293T C165(1.21)  LDD1521  [3]
 LDCM0288  AC28 HEK-293T C165(1.02)  LDD1527  [3]
 LDCM0291  AC30 HEK-293T C165(0.98)  LDD1530  [3]
 LDCM0297  AC36 HEK-293T C165(1.00)  LDD1536  [3]
 LDCM0299  AC38 HEK-293T C165(1.11)  LDD1538  [3]
 LDCM0301  AC4 HEK-293T C165(0.97)  LDD1540  [3]
 LDCM0306  AC44 HEK-293T C165(1.13)  LDD1545  [3]
 LDCM0308  AC46 HEK-293T C165(1.04)  LDD1547  [3]
 LDCM0315  AC52 HEK-293T C165(1.11)  LDD1554  [3]
 LDCM0317  AC54 HEK-293T C165(1.08)  LDD1556  [3]
 LDCM0323  AC6 HEK-293T C165(1.12)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C165(1.03)  LDD1563  [3]
 LDCM0326  AC62 HEK-293T C165(1.01)  LDD1565  [3]
 LDCM0368  CL10 HEK-293T C165(1.00)  LDD1572  [3]
 LDCM0371  CL102 HEK-293T C165(1.01)  LDD1575  [3]
 LDCM0375  CL106 HEK-293T C165(1.14)  LDD1579  [3]
 LDCM0380  CL110 HEK-293T C165(0.99)  LDD1584  [3]
 LDCM0384  CL114 HEK-293T C165(1.09)  LDD1588  [3]
 LDCM0388  CL118 HEK-293T C165(1.06)  LDD1592  [3]
 LDCM0393  CL122 HEK-293T C165(1.09)  LDD1597  [3]
 LDCM0397  CL126 HEK-293T C165(1.07)  LDD1601  [3]
 LDCM0401  CL14 HEK-293T C165(1.09)  LDD1605  [3]
 LDCM0407  CL2 HEK-293T C165(1.27)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C165(1.07)  LDD1612  [3]
 LDCM0410  CL22 HEK-293T C165(1.09)  LDD1614  [3]
 LDCM0414  CL26 HEK-293T C165(1.24)  LDD1618  [3]
 LDCM0421  CL32 HEK-293T C165(1.02)  LDD1625  [3]
 LDCM0423  CL34 HEK-293T C165(1.23)  LDD1627  [3]
 LDCM0434  CL44 HEK-293T C165(1.08)  LDD1638  [3]
 LDCM0436  CL46 HEK-293T C165(1.09)  LDD1640  [3]
 LDCM0441  CL50 HEK-293T C165(1.12)  LDD1645  [3]
 LDCM0447  CL56 HEK-293T C165(1.12)  LDD1650  [3]
 LDCM0449  CL58 HEK-293T C165(1.13)  LDD1652  [3]
 LDCM0454  CL62 HEK-293T C165(1.12)  LDD1657  [3]
 LDCM0460  CL68 HEK-293T C165(1.23)  LDD1663  [3]
 LDCM0463  CL70 HEK-293T C165(1.01)  LDD1666  [3]
 LDCM0467  CL74 HEK-293T C165(1.32)  LDD1670  [3]
 LDCM0473  CL8 HEK-293T C165(0.89)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C165(1.07)  LDD1677  [3]
 LDCM0476  CL82 HEK-293T C165(1.10)  LDD1679  [3]
 LDCM0480  CL86 HEK-293T C165(1.09)  LDD1683  [3]
 LDCM0487  CL92 HEK-293T C165(1.11)  LDD1690  [3]
 LDCM0489  CL94 HEK-293T C165(1.22)  LDD1692  [3]
 LDCM0493  CL98 HEK-293T C165(1.11)  LDD1696  [3]
 LDCM0427  Fragment51 HEK-293T C165(1.05)  LDD1631  [3]
 LDCM0022  KB02 BRX211 C21(1.77)  LDD2268  [1]
 LDCM0023  KB03 A204 C165(2.80)  LDD2669  [1]
 LDCM0024  KB05 RD C165(1.50)  LDD3401  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Paired box protein Pax-2 (PAX2) . Q02962
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
LIM domain-binding protein 1 (LDB1) LDB family Q86U70

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402