Details of the Target

General Information of Target

Target ID LDTP00798
Target Name Protein-glutamine gamma-glutamyltransferase 5 (TGM5)
Gene Name TGM5
Gene ID 9333
Synonyms
TGMX; Protein-glutamine gamma-glutamyltransferase 5; EC 2.3.2.13; Transglutaminase X; TG(X); TGX; TGase X; Transglutaminase-5; TGase-5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV
VETGPLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIH
IDSFQGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCP
WNYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNG
NWSENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVIT
NFDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLD
ATPQEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDT
SSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQP
SRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLK
VNLSAQSLLHDGSPLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALG
EEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGS
GLFKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL
Target Bioclass
Enzyme
Family
Transglutaminase superfamily, Transglutaminase family
Subcellular location
Cytoplasm
Function Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.
Uniprot ID
O43548
Ensemble ID
ENST00000220420.10
HGNC ID
HGNC:11781

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO678 SNV: p.F663V .
HCT15 SNV: p.L9I .
HEC1B SNV: p.F204V .
KYSE30 Substitution: p.G72R .
MCC13 SNV: p.S568Y .
MFE319 SNV: p.D192N .
PANC1 SNV: p.K675I .
RKO Insertion: p.R500SfsTer4 .
SKMEL5 SNV: p.S534F .
TE1 Deletion: p.L555RfsTer39 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C291(2.07)  LDD3311  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
MPP-AC
 Probe Info  		N.A.  LDD0428  [3]
TER-AC
 Probe Info  		N.A.  LDD0426  [3]
TPP-AC
 Probe Info  		N.A.  LDD0427  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 786-O C291(1.38)  LDD2247  [1]
 LDCM0023  KB03 786-O C291(1.69)  LDD2664  [1]
 LDCM0024  KB05 G361 C291(2.07)  LDD3311  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-6 (CASP6) Peptidase C14A family P55212
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin-interacting protein 1 (HIP1) SLA2 family O00291
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Galectin-7 (LGALS7; LGALS7B) . P47929
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
RNA-binding protein 41 (RBM41) . Q96IZ5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
L-glutamine Small molecular drug DB00130

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.