Details of the Target

General Information of Target

Target ID LDTP00797
Target Name DNA repair protein XRCC2 (XRCC2)
Gene Name XRCC2
Gene ID 7516
Synonyms
DNA repair protein XRCC2; X-ray repair cross-complementing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCSAFHRAESGTELLARLEGRSSLKEIEPNLFADEDSPVHGDILEFHGPEGTGKTEMLYH
LTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEHRLSQSSEEIIKYCLGRFFLVYC
SSSTHLLLTLYSLESMFCSHPSLCLLILDSLSAFYWIDRVNGGESVNLQESTLRKCSQCL
EKLVNDYRLVLFATTQTIMQKASSSSEEPSHASRRLCDVDIDYRPYLCKAWQQLVKHRMF
FSKQDDSQSSNQFSLVSRCLKSNSLKKHFFIIGESGVEFC
Target Bioclass
Other
Family
RecA family, RAD51 subfamily
Subcellular location
Nucleus
Function
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
Uniprot ID
O43543
Ensemble ID
ENST00000359321.2
HGNC ID
HGNC:12829

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C179(1.04)  LDD1508  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]
VSF
 Probe Info  		N.A.  LDD0007  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C179(1.04)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C179(1.18)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C179(1.02)  LDD1510  [1]
 LDCM0270  AC15 HEK-293T C179(0.88)  LDD1513  [1]
 LDCM0277  AC18 HEK-293T C179(1.01)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C179(0.99)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C179(1.06)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C179(1.05)  LDD1519  [1]
 LDCM0283  AC23 HEK-293T C179(0.92)  LDD1522  [1]
 LDCM0286  AC26 HEK-293T C179(1.07)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C179(1.10)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C179(1.20)  LDD1527  [1]
 LDCM0290  AC3 HEK-293T C179(1.07)  LDD1529  [1]
 LDCM0292  AC31 HEK-293T C179(0.80)  LDD1531  [1]
 LDCM0295  AC34 HEK-293T C179(1.06)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C179(1.04)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C179(1.08)  LDD1536  [1]
 LDCM0300  AC39 HEK-293T C179(0.89)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C179(1.04)  LDD1540  [1]
 LDCM0304  AC42 HEK-293T C179(1.04)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C179(1.09)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C179(0.96)  LDD1545  [1]
 LDCM0309  AC47 HEK-293T C179(0.89)  LDD1548  [1]
 LDCM0313  AC50 HEK-293T C179(1.00)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C179(1.14)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C179(1.01)  LDD1554  [1]
 LDCM0318  AC55 HEK-293T C179(0.82)  LDD1557  [1]
 LDCM0321  AC58 HEK-293T C179(1.09)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C179(1.00)  LDD1561  [1]
 LDCM0324  AC60 HEK-293T C179(0.98)  LDD1563  [1]
 LDCM0327  AC63 HEK-293T C179(0.91)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C179(0.91)  LDD1568  [1]
 LDCM0367  CL1 HEK-293T C179(0.90)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C179(0.92)  LDD1574  [1]
 LDCM0372  CL103 HEK-293T C179(0.90)  LDD1576  [1]
 LDCM0374  CL105 HEK-293T C179(0.95)  LDD1578  [1]
 LDCM0376  CL107 HEK-293T C179(0.87)  LDD1580  [1]
 LDCM0378  CL109 HEK-293T C179(0.97)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C179(0.99)  LDD1583  [1]
 LDCM0381  CL111 HEK-293T C179(1.02)  LDD1585  [1]
 LDCM0383  CL113 HEK-293T C179(0.91)  LDD1587  [1]
 LDCM0385  CL115 HEK-293T C179(0.95)  LDD1589  [1]
 LDCM0387  CL117 HEK-293T C179(0.93)  LDD1591  [1]
 LDCM0389  CL119 HEK-293T C179(0.88)  LDD1593  [1]
 LDCM0392  CL121 HEK-293T C179(1.07)  LDD1596  [1]
 LDCM0394  CL123 HEK-293T C179(0.92)  LDD1598  [1]
 LDCM0396  CL125 HEK-293T C179(0.90)  LDD1600  [1]
 LDCM0398  CL127 HEK-293T C179(0.95)  LDD1602  [1]
 LDCM0400  CL13 HEK-293T C179(0.89)  LDD1604  [1]
 LDCM0402  CL15 HEK-293T C179(0.92)  LDD1606  [1]
 LDCM0405  CL18 HEK-293T C179(1.25)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C179(1.13)  LDD1610  [1]
 LDCM0408  CL20 HEK-293T C179(1.17)  LDD1612  [1]
 LDCM0411  CL23 HEK-293T C179(1.12)  LDD1615  [1]
 LDCM0413  CL25 HEK-293T C179(0.97)  LDD1617  [1]
 LDCM0415  CL27 HEK-293T C179(0.91)  LDD1619  [1]
 LDCM0418  CL3 HEK-293T C179(0.93)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C179(0.97)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C179(1.19)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C179(0.94)  LDD1625  [1]
 LDCM0424  CL35 HEK-293T C179(1.05)  LDD1628  [1]
 LDCM0426  CL37 HEK-293T C179(1.17)  LDD1630  [1]
 LDCM0428  CL39 HEK-293T C179(1.01)  LDD1632  [1]
 LDCM0432  CL42 HEK-293T C179(1.15)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C179(1.14)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C179(1.12)  LDD1638  [1]
 LDCM0437  CL47 HEK-293T C179(1.04)  LDD1641  [1]
 LDCM0439  CL49 HEK-293T C179(0.89)  LDD1643  [1]
 LDCM0445  CL54 HEK-293T C179(1.07)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C179(1.11)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C179(1.17)  LDD1650  [1]
 LDCM0450  CL59 HEK-293T C179(1.08)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C179(1.21)  LDD1654  [1]
 LDCM0453  CL61 HEK-293T C179(0.94)  LDD1656  [1]
 LDCM0455  CL63 HEK-293T C179(0.86)  LDD1658  [1]
 LDCM0458  CL66 HEK-293T C179(1.03)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C179(1.28)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C179(1.16)  LDD1663  [1]
 LDCM0462  CL7 HEK-293T C179(0.97)  LDD1665  [1]
 LDCM0464  CL71 HEK-293T C179(0.95)  LDD1667  [1]
 LDCM0466  CL73 HEK-293T C179(0.83)  LDD1669  [1]
 LDCM0471  CL78 HEK-293T C179(0.97)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C179(1.00)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C179(1.33)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C179(1.14)  LDD1677  [1]
 LDCM0477  CL83 HEK-293T C179(1.06)  LDD1680  [1]
 LDCM0479  CL85 HEK-293T C179(0.76)  LDD1682  [1]
 LDCM0481  CL87 HEK-293T C179(0.97)  LDD1684  [1]
 LDCM0485  CL90 HEK-293T C179(1.17)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C179(1.10)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C179(1.02)  LDD1690  [1]
 LDCM0490  CL95 HEK-293T C179(1.16)  LDD1693  [1]
 LDCM0492  CL97 HEK-293T C179(0.94)  LDD1695  [1]
 LDCM0494  CL99 HEK-293T C179(0.88)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C179(0.81)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C179(1.10)  LDD1671  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-2 (MEOX2) . P50222
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA repair protein RAD51 homolog 3 (RAD51C) RecA family O43502
DNA repair protein RAD51 homolog 4 (RAD51D) RecA family O75771

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764