Details of the Target

General Information of Target

Target ID LDTP00706
Target Name Interleukin-1 receptor-associated kinase-like 2 (IRAK2)
Gene Name IRAK2
Gene ID 3656
Synonyms
Interleukin-1 receptor-associated kinase-like 2; IRAK-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MACYIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKIKSMERVQGVSITREL
LWWWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASV
RKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLPTSSDSKDFST
SIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLR
ETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQG
QGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCP
VNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRS
PVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEICQKYLEKGAGRLPEDCAEALATAACL
CLRRRNTSLQEVCGSVAAVEERLRGRETLLPWSGLSEGTGSSSNTPEETDDVDNSSLDAS
SSMSVAPWAGAATPLLPTENGEGRLRVIVGREADSSSEACVGLEPPQDVTETSWQIEINE
AKRKLMENILLYKEEKVDSIELFGP
Target Bioclass
Enzyme
Family
Protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily
Function Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Uniprot ID
O43187
Ensemble ID
ENST00000256458.5
HGNC ID
HGNC:6113
ChEMBL ID
CHEMBL4105759

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C244(1.01)  LDD0078  [1]
NAIA_4
 Probe Info  		C244(0.00); C493(0.00)  LDD2226  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C79(0.48)  LDD1093  [1]
 LDCM0215  AC10 PaTu 8988t C79(0.77)  LDD1094  [1]
 LDCM0226  AC11 PaTu 8988t C79(0.73)  LDD1105  [1]
 LDCM0237  AC12 PaTu 8988t C79(0.96)  LDD1116  [1]
 LDCM0259  AC14 PaTu 8988t C79(0.84)  LDD1138  [1]
 LDCM0263  AC143 PaTu 8988t C79(0.89)  LDD1142  [1]
 LDCM0264  AC144 PaTu 8988t C79(1.16)  LDD1143  [1]
 LDCM0265  AC145 PaTu 8988t C79(0.94)  LDD1144  [1]
 LDCM0266  AC146 PaTu 8988t C79(1.10)  LDD1145  [1]
 LDCM0267  AC147 PaTu 8988t C79(1.04)  LDD1146  [1]
 LDCM0268  AC148 PaTu 8988t C79(1.01)  LDD1147  [1]
 LDCM0269  AC149 PaTu 8988t C79(1.17)  LDD1148  [1]
 LDCM0270  AC15 PaTu 8988t C79(0.81)  LDD1149  [1]
 LDCM0271  AC150 PaTu 8988t C79(1.09)  LDD1150  [1]
 LDCM0272  AC151 PaTu 8988t C79(1.44)  LDD1151  [1]
 LDCM0273  AC152 PaTu 8988t C79(1.47)  LDD1152  [1]
 LDCM0274  AC153 PaTu 8988t C79(1.17)  LDD1153  [1]
 LDCM0621  AC154 PaTu 8988t C79(1.50)  LDD2166  [1]
 LDCM0622  AC155 PaTu 8988t C79(1.37)  LDD2167  [1]
 LDCM0623  AC156 PaTu 8988t C79(1.28)  LDD2168  [1]
 LDCM0624  AC157 PaTu 8988t C79(1.20)  LDD2169  [1]
 LDCM0279  AC2 PaTu 8988t C79(0.66)  LDD1158  [1]
 LDCM0285  AC25 PaTu 8988t C79(0.91)  LDD1164  [1]
 LDCM0286  AC26 PaTu 8988t C79(0.85)  LDD1165  [1]
 LDCM0287  AC27 PaTu 8988t C79(0.99)  LDD1166  [1]
 LDCM0288  AC28 PaTu 8988t C79(0.74)  LDD1167  [1]
 LDCM0289  AC29 PaTu 8988t C79(0.90)  LDD1168  [1]
 LDCM0290  AC3 PaTu 8988t C79(0.96)  LDD1169  [1]
 LDCM0291  AC30 PaTu 8988t C79(1.05)  LDD1170  [1]
 LDCM0292  AC31 PaTu 8988t C79(1.00)  LDD1171  [1]
 LDCM0293  AC32 PaTu 8988t C79(0.88)  LDD1172  [1]
 LDCM0294  AC33 PaTu 8988t C79(0.89)  LDD1173  [1]
 LDCM0295  AC34 PaTu 8988t C79(0.56)  LDD1174  [1]
 LDCM0301  AC4 PaTu 8988t C79(0.92)  LDD1180  [1]
 LDCM0312  AC5 PaTu 8988t C79(0.45)  LDD1191  [1]
 LDCM0323  AC6 PaTu 8988t C79(1.00)  LDD1202  [1]
 LDCM0334  AC7 PaTu 8988t C79(0.85)  LDD1213  [1]
 LDCM0345  AC8 PaTu 8988t C79(0.71)  LDD1224  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C79(1.00)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C79(0.58)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C79(0.67)  LDD1154  [1]
 LDCM0020  ARS-1620 HCC44 C244(1.01)  LDD0078  [1]
 LDCM0369  CL100 PaTu 8988t C79(0.96)  LDD1248  [1]
 LDCM0370  CL101 PaTu 8988t C79(0.91)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C79(0.81)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C79(0.98)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C79(0.88)  LDD1252  [1]
 LDCM0382  CL112 PaTu 8988t C79(0.87)  LDD1261  [1]
 LDCM0383  CL113 PaTu 8988t C79(0.90)  LDD1262  [1]
 LDCM0384  CL114 PaTu 8988t C79(0.92)  LDD1263  [1]
 LDCM0385  CL115 PaTu 8988t C79(1.14)  LDD1264  [1]
 LDCM0386  CL116 PaTu 8988t C79(1.07)  LDD1265  [1]
 LDCM0486  CL91 PaTu 8988t C79(1.00)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C79(0.81)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C79(0.83)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C79(0.73)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C79(0.83)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C79(0.91)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C79(0.84)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C79(0.58)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C79(0.87)  LDD1373  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-1 receptor-associated kinase 4 (IRAK4) TKL Ser/Thr protein kinase family Q9NWZ3
Serine/threonine-protein kinase A-Raf (ARAF) TKL Ser/Thr protein kinase family P10398
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) STT3 family P46977
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3
Endoribonuclease ZC3H12A (ZC3H12A) ZC3H12 family Q5D1E8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Toll/interleukin-1 receptor domain-containing adapter protein (TIRAP) . P58753
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Toll-interacting protein (TOLLIP) Tollip family Q9H0E2
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019