Details of the Target

General Information of Target

Target ID LDTP00523
Target Name Zinc finger and BTB domain-containing protein 39 (ZBTB39)
Gene Name ZBTB39
Gene ID 9880
Synonyms
KIAA0352; Zinc finger and BTB domain-containing protein 39
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGMRIKLQSTNHPNNLLKELNKCRLSETMCDVTIVVGSRSFPAHKAVLACAAGYFQNLFL
NTGLDAARTYVVDFITPANFEKVLSFVYTSELFTDLINVGVIYEVAERLGMEDLLQACHS
TFPDLESTARAKPLTSTSESHSGTLSCPSAEPAHPLGELRGGGDYLGADRNYVLPSDAGG
SYKEEEKNVASDANHSLHLPQPPPPPPKTEDHDTPAPFTSIPSMMTQPLLGTVSTGIQTS
TSSCQPYKVQSNGDFSKNSFLTPDNAVDITTGTNSCLSNSEHSKDPGFGQMDELQLEDLG
DDDLQFEDPAEDIGTTEEVIELSDDSEDELAFGENDNRENKAMPCQVCKKVLEPNIQLIR
QHARDHVDLLTGNCKVCETHFQDRNSRVTHVLSHIGIFLFSCDMCETKFFTQWQLTLHRR
DGIFENNIIVHPNDPLPGKLGLFSGAASPELKCAACGKVLAKDFHVVRGHILDHLNLKGQ
ACSVCDQRHLNLCSLMWHTLSHLGISVFSCSVCANSFVDWHLLEKHMAVHQSLEDALFHC
RLCSQSFKSEAAYRYHVSQHKCNSGLDARPGFGLQHPALQKRKLPAEEFLGEELALQGQP
GNSKYSCKVCGKRFAHTSEFNYHRRIHTGEKPYQCKVCHKFFRGRSTIKCHLKTHSGALM
YRCTVCGHYSSTLNLMSKHVGVHKGSLPPDFTIEQTFMYIIHSKEADKNPDS
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
O15060
Ensemble ID
ENST00000300101.3
HGNC ID
HGNC:29014

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C543(1.36)  LDD3339  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C562(1.06); C147(1.09)  LDD1507  [4]
 LDCM0226  AC11 HEK-293T C147(0.90)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C562(1.08)  LDD1510  [4]
 LDCM0276  AC17 HEK-293T C562(0.97); C147(1.11)  LDD1515  [4]
 LDCM0278  AC19 HEK-293T C147(1.04)  LDD1517  [4]
 LDCM0280  AC20 HEK-293T C562(1.10)  LDD1519  [4]
 LDCM0285  AC25 HEK-293T C562(1.04); C147(0.93)  LDD1524  [4]
 LDCM0287  AC27 HEK-293T C147(0.83)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C562(0.97)  LDD1527  [4]
 LDCM0290  AC3 HEK-293T C147(0.95)  LDD1529  [4]
 LDCM0294  AC33 HEK-293T C562(1.05); C147(1.21)  LDD1533  [4]
 LDCM0296  AC35 HEK-293T C147(0.89)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C562(1.07)  LDD1536  [4]
 LDCM0301  AC4 HEK-293T C562(0.99)  LDD1540  [4]
 LDCM0303  AC41 HEK-293T C562(1.10); C147(0.96)  LDD1542  [4]
 LDCM0305  AC43 HEK-293T C147(1.01)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C562(1.16)  LDD1545  [4]
 LDCM0311  AC49 HEK-293T C562(1.16); C147(0.86)  LDD1550  [4]
 LDCM0314  AC51 HEK-293T C147(1.08)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C562(1.05)  LDD1554  [4]
 LDCM0320  AC57 HEK-293T C562(1.19); C147(0.96)  LDD1559  [4]
 LDCM0322  AC59 HEK-293T C147(0.87)  LDD1561  [4]
 LDCM0324  AC60 HEK-293T C562(0.94)  LDD1563  [4]
 LDCM0356  AKOS034007680 HEK-293T C562(1.21); C147(0.97)  LDD1570  [4]
 LDCM0367  CL1 HEK-293T C562(0.91)  LDD1571  [4]
 LDCM0369  CL100 HEK-293T C562(1.16)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C562(1.07)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C562(1.05); C118(0.99)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C562(1.16)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C562(1.10)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C562(0.97)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C562(0.98); C118(0.98)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C562(1.08)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C562(1.08)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C562(1.05)  LDD1582  [4]
 LDCM0380  CL110 HEK-293T C562(0.93); C118(1.18)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C562(1.05)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C562(1.23)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C562(1.03)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C562(0.99); C118(1.27)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C562(1.14)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C562(1.23)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C562(1.06)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C562(1.02); C118(1.01)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C562(1.19)  LDD1593  [4]
 LDCM0391  CL120 HEK-293T C562(1.19)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C562(1.06)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C562(1.05); C118(1.04)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C562(1.03)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C562(1.41)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C562(1.00)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C562(0.89); C118(1.06)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C562(1.07)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C562(1.12)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C562(1.06)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C562(0.93); C118(1.17)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C562(1.04)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C562(1.11)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C562(1.03); C147(0.84)  LDD1608  [4]
 LDCM0406  CL19 HEK-293T C147(1.14)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C562(0.94); C118(1.11)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C562(1.20)  LDD1612  [4]
 LDCM0413  CL25 HEK-293T C562(0.94)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C562(0.96); C118(0.94)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C562(1.03)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C562(1.25)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C562(1.09); C147(0.88)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C562(0.96)  LDD1622  [4]
 LDCM0420  CL31 HEK-293T C147(1.03)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C562(1.16)  LDD1625  [4]
 LDCM0426  CL37 HEK-293T C562(0.94)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C562(0.97)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C562(1.06)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C562(1.04)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C562(1.04); C147(0.98)  LDD1635  [4]
 LDCM0433  CL43 HEK-293T C147(0.80)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C562(1.15)  LDD1638  [4]
 LDCM0439  CL49 HEK-293T C562(0.97)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C562(1.08); C147(0.98)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C562(1.05); C118(0.99)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C562(1.08)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C562(1.09); C147(0.84)  LDD1647  [4]
 LDCM0446  CL55 HEK-293T C147(0.89)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C562(1.26)  LDD1650  [4]
 LDCM0453  CL61 HEK-293T C562(0.99)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C562(0.95); C118(1.18)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C562(1.15)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C562(1.09)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C562(1.11); C147(1.01)  LDD1660  [4]
 LDCM0459  CL67 HEK-293T C147(0.86)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C562(1.10)  LDD1663  [4]
 LDCM0462  CL7 HEK-293T C147(1.14)  LDD1665  [4]
 LDCM0466  CL73 HEK-293T C562(0.87)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C562(1.02); C118(0.94)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C562(1.24)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C562(1.14); C147(0.80)  LDD1673  [4]
 LDCM0472  CL79 HEK-293T C147(1.24)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C562(1.00)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C562(1.05)  LDD1677  [4]
 LDCM0479  CL85 HEK-293T C562(0.93)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C562(0.92); C118(1.03)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C562(1.01)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C562(1.04)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C562(1.08); C147(0.89)  LDD1686  [4]
 LDCM0486  CL91 HEK-293T C147(0.77)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C562(1.05)  LDD1690  [4]
 LDCM0492  CL97 HEK-293T C562(0.89)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C562(1.00); C118(0.57)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C562(1.06)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C562(1.01)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C562(1.25)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C562(0.92); C118(1.03)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C147(0.71)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C147(1.13)  LDD1497  [4]
 LDCM0024  KB05 NALM-6 C543(1.36)  LDD3339  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
26S proteasome non-ATPase regulatory subunit 2 (PSMD2) Proteasome subunit S2 family Q13200
Serine/threonine-protein kinase PLK4 (PLK4) Ser/Thr protein kinase family O00444
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Small ubiquitin-related modifier 2 (SUMO2) Ubiquitin family P61956
Small ubiquitin-related modifier 3 (SUMO3) Ubiquitin family P55854

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402