Details of the Target

General Information of Target

Target ID LDTP00467
Target Name Interferon regulatory factor 6 (IRF6)
Gene Name IRF6
Gene ID 3664
Synonyms
Interferon regulatory factor 6; IRF-6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALHPRRVRLKPWLVAQVDSGLYPGLIWLHRDSKRFQIPWKHATRHSPQQEEENTIFKAW
AVETGKYQEGVDDPDPAKWKAQLRCALNKSREFNLMYDGTKEVPMNPVKIYQVCDIPQPQ
GSIINPGSTGSAPWDEKDNDVDEEDEEDELDQSQHHVPIQDTFPFLNINGSPMAPASVGN
CSVGNCSPEAVWPKTEPLEMEVPQAPIQPFYSSPELWISSLPMTDLDIKFQYRGKEYGQT
MTVSNPQGCRLFYGDLGPMPDQEELFGPVSLEQVKFPGPEHITNEKQKLFTSKLLDVMDR
GLILEVSGHAIYAIRLCQCKVYWSGPCAPSLVAPNLIERQKKVKLFCLETFLSDLIAHQK
GQIEKQPPFEIYLCFGEEWPDGKPLERKLILVQVIPVVARMIYEMFSGDFTRSFDSGSVR
LQISTPDIKDNIVAQLKQLYRILQTQESWQPMQPTPSMQLPPALPPQ
Target Bioclass
Transcription factor
Family
IRF family
Subcellular location
Nucleus
Function
Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription.
Uniprot ID
O14896
Ensemble ID
ENST00000367021.8
HGNC ID
HGNC:6121

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.N106S .
HCT116 SNV: p.I371V; p.Q435H .
HCT15 SNV: p.K341N .
HEC1 SNV: p.C186Y DBIA    Probe Info 
IGR37 SNV: p.E143K .
IGR39 SNV: p.E143K .
LS180 Deletion: p.F57LfsTer6 DBIA    Probe Info 
LS513 SNV: p.G170S .
MFE319 SNV: p.W379Ter .
NCIH716 SNV: p.V15G .
OVK18 SNV: p.K80Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C249(0.78)  LDD0593  [1]
IA-alkyne
 Probe Info  		C347(0.00); C249(0.00)  LDD0162  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0276  AC17 HCT 116 C249(0.78)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C249(0.46)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C249(0.56)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C249(0.56)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C249(0.62)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C249(0.55)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C249(0.64)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C249(0.62)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C249(0.60)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C249(0.65)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C249(0.67)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C249(0.68)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C249(0.71)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C249(0.67)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C249(0.60)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C249(0.52)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C249(0.66)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C249(0.59)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C249(1.21)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C249(1.28)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C249(1.08)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C249(0.94)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C249(1.10)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C249(0.92)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C249(0.89)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C249(0.87)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C249(1.06)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C249(0.90)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C249(0.90)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C249(1.02)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C249(0.98)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C249(0.92)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C249(0.75)  LDD0628  [1]
 LDCM0313  AC50 HCT 116 C249(0.77)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C249(1.04)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C249(0.84)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C249(0.99)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C249(0.85)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C249(0.70)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C249(0.49)  LDD0636  [1]
 LDCM0374  CL105 HCT 116 C249(0.57)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C249(0.46)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C249(0.50)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C249(0.54)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C249(0.63)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C249(0.53)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C249(0.60)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C249(0.80)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C249(0.69)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C249(0.54)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C249(0.84)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C249(0.58)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C249(0.71)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C249(1.13)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C249(1.16)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C249(1.09)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C249(0.58)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C249(0.78)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C249(0.79)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C249(0.83)  LDD0712  [1]
 LDCM0022  KB02 A431 C19(1.45); C327(1.48)  LDD2258  [3]
 LDCM0023  KB03 A431 C19(1.71); C327(1.90)  LDD2675  [3]
 LDCM0024  KB05 SKMEL24 C347(0.94)  LDD3323  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon regulatory factor 8 (IRF8) IRF family Q02556

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840