Details of the Target

General Information of Target

Target ID LDTP00390
Target Name Actin-binding LIM protein 1 (ABLIM1)
Gene Name ABLIM1
Gene ID 3983
Synonyms
ABLIM; KIAA0059; LIMAB1; Actin-binding LIM protein 1; abLIM-1; Actin-binding LIM protein family member 1; Actin-binding double zinc finger protein; LIMAB1; Limatin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPAFLGLKCLGKLCSSEKSKVTSSERTSARGSNRKRLIVEDRRVSGTSFTAHRRATITHL
LYLCPKDYCPRGRVCNSVDPFVAHPQDPHHPSEKPVIHCHKCGEPCKGEVLRVQTKHFHI
KCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTRCHGCGEFVEGEVVTALGKTYHPN
CFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKETTFSSNCAGCGRDIKNGQALL
ALDKQWHLGCFKCKSCGKVLTGEYISKDGAPYCEKDYQGLFGVKCEACHQFITGKVLEAG
DKHYHPSCARCSRCNQMFTEGEEMYLQGSTVWHPDCKQSTKTEEKLRPTRTSSESIYSRP
GSSIPGSPGHTIYAKVDNEILDYKDLAAIPKVKAIYDIERPDLITYEPFYTSGYDDKQER
QSLGESPRTLSPTPSAEGYQDVRDRMIHRSTSQGSINSPVYSRHSYTPTTSRSPQHFHRP
GNEPSSGRNSPLPYRPDSRPLTPTYAQAPKHFHVPDQGINIYRKPPIYKQHAALAAQSKS
SEDIIKFSKFPAAQAPDPSETPKIETDHWPGPPSFAVVGPDMKRRSSGREEDDEELLRRR
QLQEEQLMKLNSGLGQLILKEEMEKESRERSSLLASRYDSPINSASHIPSSKTASLPGYG
RNGLHRPVSTDFAQYNSYGDVSGGVRDYQTLPDGHMPAMRMDRGVSMPNMLEPKIFPYEM
LMVTNRGRNKILREVDRTRLERHLAPEVFREIFGMSIQEFDRLPLWRRNDMKKKAKLF
Target Bioclass
Other
Subcellular location
Cytoplasm
Function May act as scaffold protein. May play a role in the development of the retina. Has been suggested to play a role in axon guidance.
Uniprot ID
O14639
Ensemble ID
ENST00000369253.6
HGNC ID
HGNC:78

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
Ishikawa (Heraklio) 02 ER SNV: p.A172V DBIA    Probe Info 
KMRC3 SNV: p.R400H DBIA    Probe Info 
KP4 SNV: p.G257R .
NCIH23 SNV: p.D67Y .
RKO SNV: p.T176I .
RL952 SNV: p.Y410H .
YSCCC SNV: p.E621K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y688(20.00)  LDD0260  [1]
STPyne
 Probe Info  		K546(2.86)  LDD0277  [2]
DBIA
 Probe Info  		C250(1.58)  LDD3316  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		C308(0.00); C146(0.00)  LDD2241  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
AOyne
 Probe Info  		14.20  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C273(0.96)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C273(0.93)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C273(0.96)  LDD1512  [8]
 LDCM0278  AC19 HEK-293T C273(0.97)  LDD1517  [8]
 LDCM0280  AC20 HEK-293T C273(0.98)  LDD1519  [8]
 LDCM0282  AC22 HEK-293T C273(1.06)  LDD1521  [8]
 LDCM0287  AC27 HEK-293T C273(0.94)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C273(0.91)  LDD1527  [8]
 LDCM0290  AC3 HEK-293T C273(1.06)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C273(0.94)  LDD1530  [8]
 LDCM0296  AC35 HEK-293T C273(1.15)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C273(0.95)  LDD1536  [8]
 LDCM0299  AC38 HEK-293T C273(1.06)  LDD1538  [8]
 LDCM0301  AC4 HEK-293T C273(0.90)  LDD1540  [8]
 LDCM0305  AC43 HEK-293T C273(1.14)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C273(1.00)  LDD1545  [8]
 LDCM0308  AC46 HEK-293T C273(1.00)  LDD1547  [8]
 LDCM0314  AC51 HEK-293T C273(1.01)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C273(0.92)  LDD1554  [8]
 LDCM0317  AC54 HEK-293T C273(1.02)  LDD1556  [8]
 LDCM0322  AC59 HEK-293T C273(1.03)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C273(0.93)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C273(0.95)  LDD1563  [8]
 LDCM0326  AC62 HEK-293T C273(0.91)  LDD1565  [8]
 LDCM0020  ARS-1620 HCC44 C128(1.12); C130(1.12)  LDD2171  [9]
 LDCM0367  CL1 HEK-293T C99(0.99)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C273(1.01)  LDD1572  [8]
 LDCM0370  CL101 HEK-293T C99(1.05)  LDD1574  [8]
 LDCM0374  CL105 HEK-293T C99(0.85)  LDD1578  [8]
 LDCM0378  CL109 HEK-293T C99(0.95)  LDD1582  [8]
 LDCM0383  CL113 HEK-293T C99(1.03)  LDD1587  [8]
 LDCM0387  CL117 HEK-293T C99(0.97)  LDD1591  [8]
 LDCM0392  CL121 HEK-293T C99(0.99)  LDD1596  [8]
 LDCM0396  CL125 HEK-293T C99(0.95)  LDD1600  [8]
 LDCM0400  CL13 HEK-293T C99(0.92)  LDD1604  [8]
 LDCM0406  CL19 HEK-293T C273(1.11)  LDD1610  [8]
 LDCM0408  CL20 HEK-293T C273(1.07)  LDD1612  [8]
 LDCM0410  CL22 HEK-293T C273(1.26)  LDD1614  [8]
 LDCM0413  CL25 HEK-293T C99(0.94)  LDD1617  [8]
 LDCM0420  CL31 HEK-293T C273(1.08)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C273(1.11)  LDD1625  [8]
 LDCM0423  CL34 HEK-293T C273(1.22)  LDD1627  [8]
 LDCM0426  CL37 HEK-293T C99(0.90)  LDD1630  [8]
 LDCM0433  CL43 HEK-293T C273(1.00)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C273(0.94)  LDD1638  [8]
 LDCM0436  CL46 HEK-293T C273(1.28)  LDD1640  [8]
 LDCM0439  CL49 HEK-293T C99(0.96)  LDD1643  [8]
 LDCM0446  CL55 HEK-293T C273(1.32)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C273(1.04)  LDD1650  [8]
 LDCM0449  CL58 HEK-293T C273(1.24)  LDD1652  [8]
 LDCM0453  CL61 HEK-293T C99(0.99)  LDD1656  [8]
 LDCM0459  CL67 HEK-293T C273(1.04)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C273(1.01)  LDD1663  [8]
 LDCM0462  CL7 HEK-293T C273(1.24)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C273(1.32)  LDD1666  [8]
 LDCM0466  CL73 HEK-293T C99(0.86)  LDD1669  [8]
 LDCM0472  CL79 HEK-293T C273(1.31)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C273(0.70)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C273(1.07)  LDD1677  [8]
 LDCM0476  CL82 HEK-293T C273(1.15)  LDD1679  [8]
 LDCM0479  CL85 HEK-293T C99(0.97)  LDD1682  [8]
 LDCM0486  CL91 HEK-293T C273(1.10)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C273(1.03)  LDD1690  [8]
 LDCM0489  CL94 HEK-293T C273(1.07)  LDD1692  [8]
 LDCM0492  CL97 HEK-293T C99(0.91)  LDD1695  [8]
 LDCM0022  KB02 786-O C86(1.03); C250(1.15)  LDD2247  [3]
 LDCM0023  KB03 786-O C86(1.29); C250(1.38)  LDD2664  [3]
 LDCM0024  KB05 MEL167 C250(1.58)  LDD3316  [3]
 LDCM0021  THZ1 HCT 116 C128(1.12); C130(1.12)  LDD2173  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein LDOC1 (LDOC1) LDOC1 family O95751
Caspase recruitment domain-containing protein 9 (CARD9) . Q9H257
Four and a half LIM domains protein 2 (FHL2) . Q14192
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.