Details of the Target

General Information of Target

Target ID LDTP00286
Target Name Homeobox protein Meis1 (MEIS1)
Gene Name MEIS1
Gene ID 4211
Synonyms
Homeobox protein Meis1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMA
PSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNED
IAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGK
MPIDLVIDDREGGSKSDSEDITRSANLTDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHS
GDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRAWLFQHLTHPYP
SEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVM
DGQQHMGIRAPGPMSGMGMNMGMEGQWHYM
Target Bioclass
Transcription factor
Family
TALE/MEIS homeobox family
Subcellular location
Nucleus
Function
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.
Uniprot ID
O00470
Ensemble ID
ENST00000272369.14
HGNC ID
HGNC:7000
ChEMBL ID
CHEMBL4879409

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.P43R .
A375 SNV: p.N243S .
AGS SNV: p.L86P .
DU145 SNV: p.Q332Ter .
NALM6 SNV: p.G109R; p.R276H .
NCIH2291 SNV: p.P27Q .
SW1783 SNV: p.R172W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C90(7.33)  LDD3418  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]
1c-yne
 Probe Info  		K180(0.00); K132(0.00)  LDD0228  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0471  [5]
FFF probe15
 Probe Info  		18.19  LDD0478  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CC-LP-1 C90(2.45)  LDD2298  [1]
 LDCM0023  KB03 CC-LP-1 C90(5.01)  LDD2715  [1]
 LDCM0024  KB05 SG231 C90(7.33)  LDD3418  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 1 (CREB1) BZIP family P16220
Protein C-ets-1 (ETS1) ETS family P14921
Pre-B-cell leukemia transcription factor 1 (PBX1) TALE/PBX homeobox family P40424
T-cell leukemia homeobox protein 1 (TLX1) . P31314

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.