Details of the Target

General Information of Target

Target ID LDTP20032
Target Name Leydig cell tumor 10 kDa protein homolog (C19orf53)
Gene Name C19orf53
Gene ID 28974
Synonyms
Leydig cell tumor 10 kDa protein homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKFNPFVTSDRSKNRKRHFNAPSHVRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRG
HYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIHPSKVVITRLKLDKDRKKILE
RKAKSRQVGKEKGKYKEELIEKMQE
Target Bioclass
Other
Family
UPF0390 family
Function May have a potential role in hypercalcemia of malignancy.
Uniprot ID
Q9UNZ5
Ensemble ID
ENST00000588234.6
HGNC ID
HGNC:24991

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		3.57  LDD0066  [1]
STPyne
 Probe Info  		K60(7.11); K87(8.33)  LDD0277  [2]
ATP probe
 Probe Info  		K60(0.00); K87(0.00); K17(0.00); K48(0.00)  LDD0199  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [4]

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377