Details of the Target

General Information of Target

Target ID LDTP19829
Target Name Coiled-coil domain-containing protein 12 (CCDC12)
Gene Name CCDC12
Gene ID 151903
Synonyms
Coiled-coil domain-containing protein 12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLGQLLPHTARGLGAAEMPGQGPGSDWTERSSSAEPPAVAGTEGGGGGSAGYSCYQNSKG
SDRIKDGYKVNSHIAKLQELWKTPQNQTIHLSKSMMEASFFKHPDLTTGQKRYLCSIAKI
YNANYLKMLMKRQYMHVLQHSSQKPGVLTHHRSRLSSRYSQKQHYPCTTWRHQLEREDSG
SSDIAAASAPEMLIQHSLWRPVRNKEGIKTGYASKTRCKSLKIFRRPRKLFMQTVSSDDS
ESHMSEEKKEEDLLNNFMQSMSIEEQGEHLMLT
Target Bioclass
Other
Uniprot ID
Q8WUD4
Ensemble ID
ENST00000425441.5
HGNC ID
HGNC:28332

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K117(10.00)  LDD0277  [2]
HHS-475
 Probe Info  		Y62(0.72)  LDD0264  [3]
IA-alkyne
 Probe Info  		C163(0.76)  LDD2182  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0625  F8 Ramos C163(0.80)  LDD2187  [4]
 LDCM0572  Fragment10 Ramos C163(1.45)  LDD2189  [4]
 LDCM0574  Fragment12 Ramos C163(0.99)  LDD2191  [4]
 LDCM0575  Fragment13 Ramos C163(1.15)  LDD2192  [4]
 LDCM0576  Fragment14 Ramos C163(1.09)  LDD2193  [4]
 LDCM0579  Fragment20 Ramos C163(0.91)  LDD2194  [4]
 LDCM0580  Fragment21 Ramos C163(1.38)  LDD2195  [4]
 LDCM0582  Fragment23 Ramos C163(1.26)  LDD2196  [4]
 LDCM0578  Fragment27 Ramos C163(1.07)  LDD2197  [4]
 LDCM0588  Fragment30 Ramos C163(1.51)  LDD2199  [4]
 LDCM0589  Fragment31 Ramos C163(0.96)  LDD2200  [4]
 LDCM0590  Fragment32 Ramos C163(1.29)  LDD2201  [4]
 LDCM0468  Fragment33 Ramos C163(1.55)  LDD2202  [4]
 LDCM0596  Fragment38 Ramos C163(0.92)  LDD2203  [4]
 LDCM0566  Fragment4 Ramos C163(0.95)  LDD2184  [4]
 LDCM0610  Fragment52 Ramos C163(1.28)  LDD2204  [4]
 LDCM0614  Fragment56 Ramos C163(1.10)  LDD2205  [4]
 LDCM0569  Fragment7 Ramos C163(1.14)  LDD2186  [4]
 LDCM0571  Fragment9 Ramos C163(1.18)  LDD2188  [4]
 LDCM0116  HHS-0101 DM93 Y62(0.72)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y62(1.15)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y62(0.90)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y62(0.91)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y62(0.91)  LDD0268  [3]
 LDCM0022  KB02 Ramos C163(0.76)  LDD2182  [4]
 LDCM0023  KB03 Ramos C163(0.88)  LDD2183  [4]
 LDCM0024  KB05 Ramos C163(0.81)  LDD2185  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Autophagy protein 5 (ATG5) ATG5 family Q9H1Y0
Crooked neck-like protein 1 (CRNKL1) Crooked-neck family Q9BZJ0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.