Details of the Target

General Information of Target

Target ID LDTP19567
Target Name RNA-binding protein 43 (RBM43)
Gene Name RBM43
Gene ID 375287
Synonyms
C2orf38; RNA-binding protein 43; RNA-binding motif protein 43
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVQREKARDNFEGGCLAELIGSPRDWKCFLAVPDPLLGVQHWLHLWRPQTKDGNSLHRHG
DQAWGKHRRQNSLKSPALSGHSIDYHFYPRLRCGMLIGPDKQAVASGLEVLVTSSTKILG
QLFPDAAHFLEEASEFKAE
Target Bioclass
Other
Uniprot ID
Q6ZSC3
Ensemble ID
ENST00000331426.6
HGNC ID
HGNC:24790

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C260(20.00)  LDD2227  [1]
DBIA
 Probe Info  		C313(8.32)  LDD0204  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0102  BDHI 8 Jurkat C313(8.32)  LDD0204  [2]
 LDCM0632  CL-Sc Hep-G2 C260(20.00)  LDD2227  [1]
 LDCM0022  KB02 CHL1 C313(1.77)  LDD2475  [3]
 LDCM0023  KB03 COLO792 C313(2.50)  LDD2893  [3]
 LDCM0024  KB05 G361 C313(2.91)  LDD3311  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DAZ-associated protein 2 (DAZAP2) . Q15038

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840