Details of the Target

General Information of Target

Target ID LDTP19457
Target Name Transmembrane protein 268 (TMEM268)
Gene Name TMEM268
Gene ID 203197
Synonyms
C9orf91; Transmembrane protein 268
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDLWLFLLLPLSAFHGVKGCLECDPKFIEDVGSLLGNLIPSEVPGRTQLLERQIKEMIH
LSFKVSHSDKRLRVLAVQQVVKLRTWLKNEFYKLGNETWKGVFIYQGKLLDVCQNLESKL
KELLKNFSEIACSEDCIVVEGPILDCWTCLRMTNRCFKGEYCGDEDPRKAENREIALFLI
LLATAVILGSAVLLFHFCIFHRRKMKAIRRSLKEYVEKKLEELMGKIDEKEEKDFRLRK
Target Bioclass
Other
Subcellular location
Membrane
Uniprot ID
Q5VZI3
Ensemble ID
ENST00000288502.9
HGNC ID
HGNC:24513

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KMCH1 Deletion: p.A126LfsTer27 .
MDAMB453 SNV: p.E153Q .
MEWO SNV: p.L210S .
MFE319 SNV: p.D8Y .
NCIH2170 SNV: p.E328Ter .
SW756 SNV: p.E281K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C52(2.68)  LDD0170  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C52(2.68)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C52(4.72)  LDD0171  [1]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625