Details of the Target

General Information of Target

Target ID LDTP19418
Target Name PX domain-containing protein 1 (PXDC1)
Gene Name PXDC1
Gene ID 221749
Synonyms
C6orf145; PX domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAYGMPMYKSGDLVFAKLKGYAHWPARIEHMTQPNRYQVFFFGTHETAFLSPKRLFPYK
ECKEKFGKPNKRRGFSAGLWEIENNPTVQASDCPLASEKGSGDGPWPEPEAAEGDEDKPT
HAGGGGDELGKPDDDKPTEEEKGPLKRSAGDPPEDAPKRPKEAAPDQEEEAEAERAAEAE
RAAAAAAATAVDEESPFLVAVENGSAPSEPGLVCEPPQPEEEELREEEVADEEASQEWHA
EAPGGGDRDSL
Target Bioclass
Other
Uniprot ID
Q5TGL8
Ensemble ID
ENST00000380283.5
HGNC ID
HGNC:21361

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K91(4.73)  LDD0277  [1]
DBIA
 Probe Info  		C115(2.45)  LDD3314  [2]
IPM
 Probe Info  		C115(0.00); C164(0.00)  LDD0147  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C115(0.99)  LDD1507  [4]
 LDCM0237  AC12 HEK-293T C115(0.97)  LDD1510  [4]
 LDCM0276  AC17 HEK-293T C115(0.93)  LDD1515  [4]
 LDCM0280  AC20 HEK-293T C115(0.92)  LDD1519  [4]
 LDCM0285  AC25 HEK-293T C115(1.01)  LDD1524  [4]
 LDCM0288  AC28 HEK-293T C115(1.01)  LDD1527  [4]
 LDCM0294  AC33 HEK-293T C115(1.00)  LDD1533  [4]
 LDCM0297  AC36 HEK-293T C115(0.98)  LDD1536  [4]
 LDCM0301  AC4 HEK-293T C115(0.91)  LDD1540  [4]
 LDCM0303  AC41 HEK-293T C115(1.06)  LDD1542  [4]
 LDCM0306  AC44 HEK-293T C115(1.00)  LDD1545  [4]
 LDCM0311  AC49 HEK-293T C115(1.09)  LDD1550  [4]
 LDCM0315  AC52 HEK-293T C115(1.06)  LDD1554  [4]
 LDCM0320  AC57 HEK-293T C115(0.96)  LDD1559  [4]
 LDCM0324  AC60 HEK-293T C115(1.08)  LDD1563  [4]
 LDCM0356  AKOS034007680 HEK-293T C115(0.98)  LDD1570  [4]
 LDCM0404  CL17 HEK-293T C115(1.12)  LDD1608  [4]
 LDCM0408  CL20 HEK-293T C115(1.00)  LDD1612  [4]
 LDCM0417  CL29 HEK-293T C115(1.01)  LDD1621  [4]
 LDCM0421  CL32 HEK-293T C115(0.97)  LDD1625  [4]
 LDCM0431  CL41 HEK-293T C115(1.00)  LDD1635  [4]
 LDCM0434  CL44 HEK-293T C115(1.06)  LDD1638  [4]
 LDCM0440  CL5 HEK-293T C115(1.10)  LDD1644  [4]
 LDCM0444  CL53 HEK-293T C115(0.97)  LDD1647  [4]
 LDCM0447  CL56 HEK-293T C115(1.15)  LDD1650  [4]
 LDCM0457  CL65 HEK-293T C115(0.96)  LDD1660  [4]
 LDCM0460  CL68 HEK-293T C115(1.05)  LDD1663  [4]
 LDCM0470  CL77 HEK-293T C115(1.19)  LDD1673  [4]
 LDCM0473  CL8 HEK-293T C115(0.87)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C115(1.14)  LDD1677  [4]
 LDCM0483  CL89 HEK-293T C115(1.16)  LDD1686  [4]
 LDCM0487  CL92 HEK-293T C115(0.99)  LDD1690  [4]
 LDCM0022  KB02 HEK-293T C115(0.93)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C115(1.03)  LDD1497  [4]
 LDCM0024  KB05 IGR37 C115(2.45)  LDD3314  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402