Details of the Target

General Information of Target

Target ID LDTP19416
Target Name Sterile alpha motif domain-containing protein 5 (SAMD5)
Gene Name SAMD5
Gene ID 389432
Synonyms
SAMDC1; Sterile alpha motif domain-containing protein 5; SAM domain-containing protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSARPSLPPLPAKPAGSPRLRERPAPVGPGGEDAYSLLLRPQLGTRKVARAEEAGGEEGK
REAEAWTRRAAASARRGGELRTEEPPPPAARLCCLGGGCGGGGGGGQKVSATASIPFSCK
RALLTSTIPLSPPAKRRGIRTWGHPSYLTPSPTMRD
Target Bioclass
Other
Subcellular location
Cytoplasm
Uniprot ID
Q5TGI4
Ensemble ID
ENST00000367474.2
HGNC ID
HGNC:21180

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C99(0.94)  LDD3341  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C99(1.04)  LDD1508  [2]
 LDCM0270  AC15 HEK-293T C99(0.73)  LDD1513  [2]
 LDCM0277  AC18 HEK-293T C99(0.98)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C99(0.97)  LDD1518  [2]
 LDCM0283  AC23 HEK-293T C99(0.71)  LDD1522  [2]
 LDCM0286  AC26 HEK-293T C99(0.89)  LDD1525  [2]
 LDCM0292  AC31 HEK-293T C99(0.99)  LDD1531  [2]
 LDCM0295  AC34 HEK-293T C99(1.01)  LDD1534  [2]
 LDCM0300  AC39 HEK-293T C99(1.00)  LDD1539  [2]
 LDCM0304  AC42 HEK-293T C99(1.02)  LDD1543  [2]
 LDCM0309  AC47 HEK-293T C99(0.96)  LDD1548  [2]
 LDCM0313  AC50 HEK-293T C99(1.04)  LDD1552  [2]
 LDCM0318  AC55 HEK-293T C99(0.98)  LDD1557  [2]
 LDCM0321  AC58 HEK-293T C99(0.90)  LDD1560  [2]
 LDCM0327  AC63 HEK-293T C99(1.01)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C99(0.95)  LDD1568  [2]
 LDCM0371  CL102 HEK-293T C99(0.95)  LDD1575  [2]
 LDCM0375  CL106 HEK-293T C99(1.00)  LDD1579  [2]
 LDCM0379  CL11 HEK-293T C99(1.21)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C99(0.84)  LDD1584  [2]
 LDCM0384  CL114 HEK-293T C99(0.90)  LDD1588  [2]
 LDCM0388  CL118 HEK-293T C99(0.99)  LDD1592  [2]
 LDCM0393  CL122 HEK-293T C99(0.83)  LDD1597  [2]
 LDCM0397  CL126 HEK-293T C99(0.76)  LDD1601  [2]
 LDCM0401  CL14 HEK-293T C99(0.95)  LDD1605  [2]
 LDCM0405  CL18 HEK-293T C99(0.89)  LDD1609  [2]
 LDCM0407  CL2 HEK-293T C99(0.93)  LDD1611  [2]
 LDCM0411  CL23 HEK-293T C99(0.77)  LDD1615  [2]
 LDCM0414  CL26 HEK-293T C99(1.07)  LDD1618  [2]
 LDCM0419  CL30 HEK-293T C99(0.98)  LDD1623  [2]
 LDCM0424  CL35 HEK-293T C99(0.79)  LDD1628  [2]
 LDCM0432  CL42 HEK-293T C99(0.85)  LDD1636  [2]
 LDCM0437  CL47 HEK-293T C99(1.13)  LDD1641  [2]
 LDCM0441  CL50 HEK-293T C99(1.17)  LDD1645  [2]
 LDCM0445  CL54 HEK-293T C99(0.91)  LDD1648  [2]
 LDCM0450  CL59 HEK-293T C99(0.96)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C99(1.12)  LDD1654  [2]
 LDCM0454  CL62 HEK-293T C99(0.92)  LDD1657  [2]
 LDCM0458  CL66 HEK-293T C99(1.08)  LDD1661  [2]
 LDCM0464  CL71 HEK-293T C99(1.11)  LDD1667  [2]
 LDCM0467  CL74 HEK-293T C99(1.07)  LDD1670  [2]
 LDCM0471  CL78 HEK-293T C99(0.97)  LDD1674  [2]
 LDCM0477  CL83 HEK-293T C99(0.92)  LDD1680  [2]
 LDCM0480  CL86 HEK-293T C99(1.03)  LDD1683  [2]
 LDCM0485  CL90 HEK-293T C99(0.98)  LDD1688  [2]
 LDCM0490  CL95 HEK-293T C99(1.44)  LDD1693  [2]
 LDCM0493  CL98 HEK-293T C99(1.05)  LDD1696  [2]
 LDCM0427  Fragment51 HEK-293T C99(0.85)  LDD1631  [2]
 LDCM0022  KB02 A2058 C99(1.58)  LDD2253  [1]
 LDCM0023  KB03 A2058 C99(1.53)  LDD2670  [1]
 LDCM0024  KB05 NCI-H1048 C99(0.94)  LDD3341  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402