Details of the Target

General Information of Target

Target ID LDTP19222
Target Name Coiled-coil domain-containing protein 15 (CCDC15)
Gene Name CCDC15
Gene ID 80071
Synonyms
Coiled-coil domain-containing protein 15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MENQLWHNTVRCCNQYQESPHDAEDILLLLLGLIVLVNIGINVATMMWHGLQNALDKMID
WATQKNEIQASESPPSGPPDKAQDVHIHCILDPVQVKMSRPTQYSSFSCHHFSNHHSSSL
LRCVRRRRRRHRRCRRRCCNHQQRPQNYRQIPHSHSVFRNPHRSQKMSQLHRVPFFDQED
PDSYLEEEDNLPFPYPKYPRRGWGGFYQRAGLPSNVGLWGHQGGILASLPPPSLYLSPEL
RCMPKRVEARSELRLQSYGRHGSQSRLWGNVEAEQWASSPPPPHRLPPNPSWVPVGHSPY
PSVGWMLYDSWDQRRRGTEGFERPPASVSRNARPEAQGCREHHSPQSHQQSLLGHAYGQS
HRSPHPSTEPLGYSSQDPREVRRRAADWAEALPAWRPLTTSASLTVLDEASHQRTPAPSS
VLVPHSSQPWPKVQAADPAPPPTMFVPLSRNPGGNANYQVYDSLELKRQVQKSRARSSSL
PPASTSTLRPSLHRSQTEKLN
Target Bioclass
Other
Uniprot ID
Q0P6D6
Ensemble ID
ENST00000344762.6
HGNC ID
HGNC:25798

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C432(1.14)  LDD2128  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C432(1.14)  LDD2128  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C432(0.64)  LDD2140  [1]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C432(3.87)  LDD2147  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761