Details of the Target

General Information of Target

Target ID LDTP18891
Target Name Putative histone PARylation factor 1-like
Synonyms
Putative histone PARylation factor 1-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGMYLLHIGNAAVTFNGPTPCPRSPYASTHVNVSWESASGIATLWANGKLVGRKGVWKGY
SVGEEAKIILGQEQDSFGGHFDENQSFVGVIWDVFLWDHVLPPKEMCDSCYSGSLLNRHT
LTYEDNGYVVTKPKVWA
Target Bioclass
Enzyme
Family
HPF1 family
Uniprot ID
A8MVJ9

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C30(2.03)  LDD0169  [1]
DBIA
 Probe Info  		C30(1.23); C153(0.98)  LDD0080  [2]
Methacrolein
 Probe Info  		N.A.  LDD0218  [3]
NAIA_5
 Probe Info  		C30(0.00); C153(0.00)  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C30(2.03)  LDD0169  [1]
 LDCM0022  KB02 HCT 116 C30(1.23); C153(0.98)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C30(1.12); C153(1.07)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C30(1.43); C153(1.06)  LDD0082  [2]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264