Details of the Target

General Information of Target

Target ID LDTP18554
Target Name Sex comb on midleg-like protein 1 (SCML1)
Gene Name SCML1
Gene ID 6322
Synonyms
Sex comb on midleg-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASNERDAISWYQKKIGAYDQQIWEKSIEQTQIKGLKNKPKKMGHIKPDLIDVDLIRGST
FAKAKPEIPWTSLTRKGLVRVVFFPLFSNWWIQVTSLRIFVWLLLLYFMQVIAIVLYLMM
PIVNISEVLGPLCLMLLMGTVHCQIVSTQITRPSGNNGNRRRRKLRKTVNGDGSRENGNN
SSDKVRGIETLESVPIIGGFWETIFGNRIKRVKLISNKGTETDNDPSCVHPIIKRRQCRP
EIRMWQTREKAKFSDGEKCRREAFRRLGNGVSDDLSSEEDGEARTQMILLRRSVEGASSD
NGCEVKNRKSILSRHLNSQVKKTTTRWCHIVRDSDSLAESEFESAAFSQGSRSGVSGGSR
SLNMSRRDSESTRHDSETEDMLWDDLLHGPECRSSVTSDSEGAHVNTLHSGTKRDPKEDV
FQQNHLFWLQNSSPSSDRVSAIIWEGNECKKMDMSVLEISGIIMSRVNAYQQGVGYQMLG
NVVTIGLAFFPFLHRLFREKSLDQLKSISAEEILTLFCGAPPVTPIIVLSIINFFERLCL
TWMFFFMMCVAERTYKQRFLFAKLFSHITSARKARKYEIPHFRLKKVENIKIWLSLRSYL
KRRGPQRSVDVVVSSVFLLTLSIAFICCAQVLQGHKTFLNDAYNWEFLIWETALLLFLLR
LASLGSETNKKYSNVSILLTEQINLYLKMEKKPNKKEQLTLVNNVLKLSTKLLKELDTPF
RLYGLTMNPLIYNITRVVILSAVSGVISDLLGFNIRLWKIKS
Target Bioclass
Other
Family
SCM family
Subcellular location
Nucleus
Function
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation.
Uniprot ID
Q9UN30
Ensemble ID
ENST00000380041.8
HGNC ID
HGNC:10580

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C276(2.30)  LDD0168  [1]
DBIA
 Probe Info  		C276(1.05)  LDD1507  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C276(2.30)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C276(3.30)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C276(1.05)  LDD1507  [2]
 LDCM0276  AC17 HEK-293T C276(1.31)  LDD1515  [2]
 LDCM0285  AC25 HEK-293T C276(0.87)  LDD1524  [2]
 LDCM0294  AC33 HEK-293T C276(0.97)  LDD1533  [2]
 LDCM0303  AC41 HEK-293T C276(0.91)  LDD1542  [2]
 LDCM0311  AC49 HEK-293T C276(1.10)  LDD1550  [2]
 LDCM0320  AC57 HEK-293T C276(0.97)  LDD1559  [2]
 LDCM0356  AKOS034007680 HEK-293T C276(1.06)  LDD1570  [2]
 LDCM0404  CL17 HEK-293T C276(1.42)  LDD1608  [2]
 LDCM0417  CL29 HEK-293T C276(0.87)  LDD1621  [2]
 LDCM0431  CL41 HEK-293T C276(1.23)  LDD1635  [2]
 LDCM0440  CL5 HEK-293T C276(0.98)  LDD1644  [2]
 LDCM0444  CL53 HEK-293T C276(1.16)  LDD1647  [2]
 LDCM0457  CL65 HEK-293T C276(0.95)  LDD1660  [2]
 LDCM0470  CL77 HEK-293T C276(1.29)  LDD1673  [2]
 LDCM0483  CL89 HEK-293T C276(0.96)  LDD1686  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-acylglucosamine 2-epimerase (RENBP) N-acylglucosamine 2-epimerase family P51606
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Integrin beta-2 (ITGB2) Integrin beta chain family P05107
Scm-like with four MBT domains protein 2 (SFMBT2) . Q5VUG0

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.