Details of the Target

General Information of Target

Target ID LDTP18549
Target Name Zinc finger protein 608 (ZNF608)
Gene Name ZNF608
Gene ID 57507
Synonyms
KIAA1281; Zinc finger protein 608; Renal carcinoma antigen NY-REN-36
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAVTFEDVTIIFTWEEWKFLDSSQKRLYREVMWENYTNVMSVENWNESYKSQEEKFRYLE
YENFSYWQGWWNAGAQMYENQNYGETVQGTDSKDLTQQDRSQCQEWLILSTQVPGYGNYE
LTFESKSLRNLKYKNFMPWQSLETKTTQDYGREIYMSGSHGFQGGRYRLGISRKNLSMEK
EQKLIVQHSYIPVEEALPQYVGVICQEDLLRDSMEEKYCGCNKCKGIYYWNSRCVFHKRN
QPGENLCQCSICKACFSQRSDLYRHPRNHIGKKLYGCDEVDGNFHQSSGVHFHQRVHIGE
VPYSCNACGKSFSQISSLHNHQRVHTEEKFYKIECDKDLSRNSLLHIHQRLHIGEKPFKC
NQCGKSFNRSSVLHVHQRVHTGEKPYKCDECGKGFSQSSNLRIHQLVHTGEKSYKCEDCG
KGFTQRSNLQIHQRVHTGEKPYKCDDCGKDFSHSSDLRIHQRVHTGEKPYTCPECGKGFS
KSSKLHTHQRVHTGEKPYKCEECGKGFSQRSHLLIHQRVHTGEKPYKCHDCGKGFSHSSN
LHIHQRVHTGEKPYQCAKCGKGFSHSSALRIHQRVHAGEKPYKCREYYKGFDHNSHLHNN
HRRGNL
Target Bioclass
Other
Function Transcription factor, which represses ZNF609 transcription.
Uniprot ID
Q9ULD9
Ensemble ID
ENST00000306315.9
HGNC ID
HGNC:29238

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.P1481S .
HCT15 SNV: p.T1466A .
HT115 SNV: p.K209R .
HT1197 SNV: p.N561Y .
Ishikawa (Heraklio) 02 ER SNV: p.G185V; p.R417M .
JEKO1 Deletion: p.S131KfsTer10 .
K562 SNV: p.G1015A .
KMCH1 SNV: p.Y1387H .
KMS11 Deletion: p.Q1224RfsTer4 .
MFE319 SNV: p.S477N .
MIAPACA2 SNV: p.A1038D .
MOLM13 SNV: p.P1134L .
NCIH358 SNV: p.D1236E .
OVISE SNV: p.S1279G .
SUPT1 Deletion: p.H234TfsTer49
SNV: p.V266A		 .
SW1116 SNV: p.E145Q .
TOV21G SNV: p.V17I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C65(2.34)  LDD3403  [1]
Phosphinate-6
 Probe Info  		C1127(0.00); C723(0.00)  LDD0018  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C65(1.11)  LDD1508  [3]
 LDCM0237  AC12 HEK-293T C65(1.10)  LDD1510  [3]
 LDCM0277  AC18 HEK-293T C65(0.93)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C65(1.04)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C65(0.94)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C65(1.08)  LDD1520  [3]
 LDCM0286  AC26 HEK-293T C65(1.03)  LDD1525  [3]
 LDCM0288  AC28 HEK-293T C65(0.97)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C65(1.01)  LDD1528  [3]
 LDCM0295  AC34 HEK-293T C65(1.09)  LDD1534  [3]
 LDCM0297  AC36 HEK-293T C65(1.20)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C65(0.97)  LDD1537  [3]
 LDCM0301  AC4 HEK-293T C65(1.15)  LDD1540  [3]
 LDCM0304  AC42 HEK-293T C65(1.22)  LDD1543  [3]
 LDCM0306  AC44 HEK-293T C65(0.86)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C65(1.04)  LDD1546  [3]
 LDCM0312  AC5 HEK-293T C65(0.83)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C65(1.19)  LDD1552  [3]
 LDCM0315  AC52 HEK-293T C65(1.03)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C65(1.05)  LDD1555  [3]
 LDCM0321  AC58 HEK-293T C65(1.02)  LDD1560  [3]
 LDCM0324  AC60 HEK-293T C65(1.01)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C65(0.89)  LDD1564  [3]
 LDCM0248  AKOS034007472 HEK-293T C65(1.06)  LDD1511  [3]
 LDCM0405  CL18 HEK-293T C65(1.18)  LDD1609  [3]
 LDCM0408  CL20 HEK-293T C65(1.07)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C65(1.05)  LDD1613  [3]
 LDCM0419  CL30 HEK-293T C65(1.04)  LDD1623  [3]
 LDCM0421  CL32 HEK-293T C65(0.98)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C65(0.97)  LDD1626  [3]
 LDCM0432  CL42 HEK-293T C65(1.01)  LDD1636  [3]
 LDCM0434  CL44 HEK-293T C65(1.14)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C65(1.07)  LDD1639  [3]
 LDCM0445  CL54 HEK-293T C65(1.09)  LDD1648  [3]
 LDCM0447  CL56 HEK-293T C65(1.06)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C65(0.89)  LDD1651  [3]
 LDCM0451  CL6 HEK-293T C65(1.12)  LDD1654  [3]
 LDCM0458  CL66 HEK-293T C65(1.06)  LDD1661  [3]
 LDCM0460  CL68 HEK-293T C65(1.13)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C65(1.09)  LDD1664  [3]
 LDCM0471  CL78 HEK-293T C65(1.09)  LDD1674  [3]
 LDCM0473  CL8 HEK-293T C65(0.87)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C65(1.14)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C65(1.22)  LDD1678  [3]
 LDCM0484  CL9 HEK-293T C65(1.02)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C65(0.85)  LDD1688  [3]
 LDCM0487  CL92 HEK-293T C65(1.09)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C65(1.08)  LDD1691  [3]
 LDCM0022  KB02 697 C65(1.70)  LDD2245  [1]
 LDCM0023  KB03 697 C65(1.74)  LDD2662  [1]
 LDCM0024  KB05 Reh C65(2.34)  LDD3403  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402