Details of the Target

General Information of Target

Target ID LDTP18537
Target Name SH3 domain-binding glutamic acid-rich-like protein 2 (SH3BGRL2)
Gene Name SH3BGRL2
Gene ID 83699
Synonyms
FASH3; SH3 domain-binding glutamic acid-rich-like protein 2; Fovea-associated SH3 domain-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFCGDYVQGTIFPAPNFNPIMDAQMLGGALQGFDCDKDMLINILTQRCNAQRMMIAEAYQ
SMYGRDLIGDMREQLSDHFKDVMAGLMYPPPLYDAHELWHAMKGVGTDENCLIEILASRT
NGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNLVQGTREEGYTDPAMAAQDAMVL
WEACQQKTGEHKTMLQMILCNKSYQQLRLVFQEFQNISGQDMVDAINECYDGYFQELLVA
IVLCVRDKPAYFAYRLYSAIHDFGFHNKTVIRILIARSEIDLLTIRKRYKERYGKSLFHD
IRNFASGHYKKALLAICAGDAEDY
Target Bioclass
Other
Family
SH3BGR family
Subcellular location
Nucleus
Uniprot ID
Q9UJC5
Ensemble ID
ENST00000369838.6
HGNC ID
HGNC:15567

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C76(2.54)  LDD3368  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C76(0.85)  LDD1507  [3]
 LDCM0259  AC14 HEK-293T C76(0.96)  LDD1512  [3]
 LDCM0276  AC17 HEK-293T C76(0.94)  LDD1515  [3]
 LDCM0282  AC22 HEK-293T C76(0.92)  LDD1521  [3]
 LDCM0285  AC25 HEK-293T C76(1.11)  LDD1524  [3]
 LDCM0291  AC30 HEK-293T C76(0.97)  LDD1530  [3]
 LDCM0294  AC33 HEK-293T C76(0.74)  LDD1533  [3]
 LDCM0299  AC38 HEK-293T C76(1.19)  LDD1538  [3]
 LDCM0303  AC41 HEK-293T C76(0.93)  LDD1542  [3]
 LDCM0308  AC46 HEK-293T C76(1.21)  LDD1547  [3]
 LDCM0311  AC49 HEK-293T C76(0.85)  LDD1550  [3]
 LDCM0317  AC54 HEK-293T C76(1.11)  LDD1556  [3]
 LDCM0320  AC57 HEK-293T C76(1.04)  LDD1559  [3]
 LDCM0323  AC6 HEK-293T C76(1.15)  LDD1562  [3]
 LDCM0326  AC62 HEK-293T C76(1.05)  LDD1565  [3]
 LDCM0356  AKOS034007680 HEK-293T C76(0.78)  LDD1570  [3]
 LDCM0368  CL10 HEK-293T C76(1.23)  LDD1572  [3]
 LDCM0404  CL17 HEK-293T C76(0.91)  LDD1608  [3]
 LDCM0410  CL22 HEK-293T C76(1.26)  LDD1614  [3]
 LDCM0417  CL29 HEK-293T C76(0.92)  LDD1621  [3]
 LDCM0423  CL34 HEK-293T C76(1.32)  LDD1627  [3]
 LDCM0431  CL41 HEK-293T C76(0.95)  LDD1635  [3]
 LDCM0436  CL46 HEK-293T C76(1.64)  LDD1640  [3]
 LDCM0440  CL5 HEK-293T C76(0.88)  LDD1644  [3]
 LDCM0444  CL53 HEK-293T C76(1.13)  LDD1647  [3]
 LDCM0449  CL58 HEK-293T C76(1.34)  LDD1652  [3]
 LDCM0457  CL65 HEK-293T C76(0.83)  LDD1660  [3]
 LDCM0463  CL70 HEK-293T C76(1.11)  LDD1666  [3]
 LDCM0470  CL77 HEK-293T C76(0.79)  LDD1673  [3]
 LDCM0476  CL82 HEK-293T C76(1.11)  LDD1679  [3]
 LDCM0483  CL89 HEK-293T C76(0.75)  LDD1686  [3]
 LDCM0489  CL94 HEK-293T C76(1.16)  LDD1692  [3]
 LDCM0022  KB02 OAW-28 C76(1.73)  LDD2534  [1]
 LDCM0023  KB03 OAW-28 C76(2.59)  LDD2951  [1]
 LDCM0024  KB05 OAW-28 C76(2.54)  LDD3368  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402