Details of the Target

General Information of Target

Target ID LDTP18533
Target Name Transgelin-3 (TAGLN3)
Gene Name TAGLN3
Gene ID 29114
Synonyms
NP25; Transgelin-3; Neuronal protein 22; NP22; Neuronal protein NP25
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKARRSPPGHHRHCEGCFNRHCHIPVEPNTSCLVISCHLLCGATFHMCKEAEHQLLCPL
EQVPCLNSEYGCPLSMSRHKLAKHLQVCPASVVCCSMEWNRWPNVDSETTLHENIMKETP
SEECLDTALALQDQKVLFRSLKMVELFPETREATEEEPTMNGETSVEEMGGAVGGVDIGL
VPHGLSATNGEMAELSQEEREVLAKTKEGMDLVKFGQWENIFSKEHAASALTNSSASCES
KNKNDSEKEQISSGHNMVEGEGAPKKKEPQENQKQQDVRTAMETTGLAPWQDGVLERLKT
AVDAKDYNMYLVHNGRMLIHFGQMPACTPKERDFVYGKLEAQEVKTVYTFKVPVSYCGKR
ARLGDAMLSCKPSEHKAVDTSDLGITVEDLPKSDLIKTTLQCALERELKGHVISESRSID
GLFMDFATQTYNFEPEQFSSGTVLADLTAATPGGLHVELHSECVTRRHNKSSSAFTFTCN
KFFRRDEFPLHFKNVHTDIQSCLNGWFQHRCPLAYLGCTFVQNHFRPPGQKAKVIYSQEL
KTFAIKPEVAPELSEGRKNNHLLGHGGKSQNSLTSLPLEILKYIAGFLDSVSLAQLSQVS
VLMRNICATLLQERGMVLLQWKKKRYSHGGTSWRVHREIWQFSSLFSKIKSWEFNEVTSM
SEHLKSCPFNIVEHKTDPILLTSMCQPREQARESLVSTFRIRPRGRYVS
Target Bioclass
Other
Family
Calponin family
Uniprot ID
Q9UI15
Ensemble ID
ENST00000273368.8
HGNC ID
HGNC:29868

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH216
 Probe Info  		Y192(20.00)  LDD0259  [1]
DBIA
 Probe Info  		C38(1.83)  LDD3344  [2]
HHS-475
 Probe Info  		Y192(0.88)  LDD0264  [3]
HHS-465
 Probe Info  		Y192(5.28)  LDD2237  [4]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DFG-out-4
 Probe Info  		6.00  LDD0075  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0017  DFG-out-2 A431 6.00  LDD0075  [5]
 LDCM0116  HHS-0101 DM93 Y192(0.88)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y192(0.84)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y192(0.81)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y192(0.80)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y192(0.96)  LDD0268  [3]
 LDCM0022  KB02 NCI-H146 C38(1.30)  LDD2510  [2]
 LDCM0023  KB03 NCI-H146 C38(1.81)  LDD2927  [2]
 LDCM0024  KB05 NCI-H146 C38(1.83)  LDD3344  [2]

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Affinity-based probes based on type II kinase inhibitors. J Am Chem Soc. 2012 Nov 21;134(46):19017-25. doi: 10.1021/ja306035v. Epub 2012 Nov 6.