Details of the Target

General Information of Target

Target ID LDTP18510
Target Name Rho GTPase-activating protein 23 (ARHGAP23)
Gene Name ARHGAP23
Gene ID 57636
Synonyms
KIAA1501; Rho GTPase-activating protein 23; Rho-type GTPase-activating protein 23
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESTAYPLNLSLKEEEEEEEIQSRELEDGPADMQKVRICSEGGWVPALFDEVAIYFSDEE
WEVLTEQQKALYREVMRMNYETVLSLEFPFPKPDMITRLEGEEESQNSDEWQLQGGTSAE
NEESDVKPPDWPNPMNATSQFPQPQHFDSFGLRLPRDITELPEWSEGYPFYMAMGFPGYD
LSADDIAGKFQFSRGMRRSYDAGFKLMVVEYAESTNNCQAAKQFGVLEKNVRDWRKVKPQ
LQNAHAMRRAFRGPKNGRFALVDQRVAEYVRYMQAKGDPITREAMQLKALEIAQEMNIPE
KGFKASLGWCRRMMRRYDLSLRHKVPVPQHLPEDLTEKLVTYQRSVLALRRAHDYEVAQM
GNADETPICLEVPSRVTVDNQGEKPVLVKTPGREKLKITAMLGVLADGRKLPPYIILRGT
YIPPGKFPSGMEIRCHRYGWMTEDLMQDWLEVVWRRRTGAVPKQRGMLILNGFRGHATDS
VKNSMESMNTDMVIIPGGLTSQLQVLDVVVYKPLNDSVRAQYSNWLLAGNLALSPTGNAK
KPPLGLFLEWVMVAWNSISSESIVQGFKKCHISSNLEEEDDVLWEIESELPGGGEPPKDC
DTESMAESN
Target Bioclass
Other
Function GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Uniprot ID
Q9P227
Ensemble ID
ENST00000610551.2
HGNC ID
HGNC:29293

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.G1378D DBIA    Probe Info 
HCT15 SNV: p.L614M .
HEC1 SNV: p.R1082H .
ICC10 SNV: p.N916K .
IGROV1 SNV: p.V1172D
Substitution: p.G1272D		 .
KMCH1 SNV: p.F985L DBIA    Probe Info 
MFE296 SNV: p.R1129G .
MFE319 SNV: p.R1389W .
MOLT4 SNV: p.A462D .
MONOMAC6 SNV: p.V1409G .
RKO Deletion: p.G852AfsTer70
SNV: p.W694Ter		 .
RPMI8226 SNV: p.D828V .
SUPT1 SNV: p.D626E .
TE1 Deletion: p.L1253_T1255del .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1261(1.77)  LDD3369  [1]
NAIA_4
 Probe Info  		C331(0.00); C392(0.00)  LDD2226  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C1261(0.53)  LDD1093  [4]
 LDCM0279  AC2 PaTu 8988t C1261(0.81)  LDD1158  [4]
 LDCM0290  AC3 PaTu 8988t C1261(0.68)  LDD1169  [4]
 LDCM0301  AC4 PaTu 8988t C1261(0.56)  LDD1180  [4]
 LDCM0312  AC5 PaTu 8988t C1261(0.66)  LDD1191  [4]
 LDCM0320  AC57 PaTu 8988t C1261(1.15)  LDD1199  [4]
 LDCM0321  AC58 PaTu 8988t C1261(1.30)  LDD1200  [4]
 LDCM0322  AC59 PaTu 8988t C1261(0.88)  LDD1201  [4]
 LDCM0324  AC60 PaTu 8988t C1261(0.87)  LDD1203  [4]
 LDCM0325  AC61 PaTu 8988t C1261(0.96)  LDD1204  [4]
 LDCM0326  AC62 PaTu 8988t C1261(0.99)  LDD1205  [4]
 LDCM0327  AC63 PaTu 8988t C1261(0.98)  LDD1206  [4]
 LDCM0328  AC64 PaTu 8988t C1261(0.64)  LDD1207  [4]
 LDCM0329  AC65 PaTu 8988t C1261(0.81)  LDD1208  [4]
 LDCM0330  AC66 PaTu 8988t C1261(1.14)  LDD1209  [4]
 LDCM0331  AC67 PaTu 8988t C1261(0.98)  LDD1210  [4]
 LDCM0332  AC68 PaTu 8988t C1261(1.08)  LDD1211  [4]
 LDCM0333  AC69 PaTu 8988t C1261(1.21)  LDD1212  [4]
 LDCM0335  AC70 PaTu 8988t C1261(1.25)  LDD1214  [4]
 LDCM0336  AC71 PaTu 8988t C1261(1.28)  LDD1215  [4]
 LDCM0337  AC72 PaTu 8988t C1261(0.73)  LDD1216  [4]
 LDCM0338  AC73 PaTu 8988t C1261(0.96)  LDD1217  [4]
 LDCM0339  AC74 PaTu 8988t C1261(1.08)  LDD1218  [4]
 LDCM0340  AC75 PaTu 8988t C1261(1.05)  LDD1219  [4]
 LDCM0341  AC76 PaTu 8988t C1261(1.12)  LDD1220  [4]
 LDCM0342  AC77 PaTu 8988t C1261(1.30)  LDD1221  [4]
 LDCM0343  AC78 PaTu 8988t C1261(1.02)  LDD1222  [4]
 LDCM0344  AC79 PaTu 8988t C1261(1.15)  LDD1223  [4]
 LDCM0346  AC80 PaTu 8988t C1261(1.08)  LDD1225  [4]
 LDCM0347  AC81 PaTu 8988t C1261(0.96)  LDD1226  [4]
 LDCM0348  AC82 PaTu 8988t C1261(1.05)  LDD1227  [4]
 LDCM0349  AC83 PaTu 8988t C1261(0.69)  LDD1228  [4]
 LDCM0350  AC84 PaTu 8988t C1261(0.96)  LDD1229  [4]
 LDCM0351  AC85 PaTu 8988t C1261(0.67)  LDD1230  [4]
 LDCM0352  AC86 PaTu 8988t C1261(0.87)  LDD1231  [4]
 LDCM0353  AC87 PaTu 8988t C1261(0.55)  LDD1232  [4]
 LDCM0354  AC88 PaTu 8988t C1261(0.63)  LDD1233  [4]
 LDCM0355  AC89 PaTu 8988t C1261(0.64)  LDD1234  [4]
 LDCM0357  AC90 PaTu 8988t C1261(1.04)  LDD1236  [4]
 LDCM0358  AC91 PaTu 8988t C1261(0.79)  LDD1237  [4]
 LDCM0359  AC92 PaTu 8988t C1261(0.87)  LDD1238  [4]
 LDCM0360  AC93 PaTu 8988t C1261(0.59)  LDD1239  [4]
 LDCM0361  AC94 PaTu 8988t C1261(0.67)  LDD1240  [4]
 LDCM0362  AC95 PaTu 8988t C1261(0.87)  LDD1241  [4]
 LDCM0363  AC96 PaTu 8988t C1261(0.62)  LDD1242  [4]
 LDCM0364  AC97 PaTu 8988t C1261(1.10)  LDD1243  [4]
 LDCM0020  ARS-1620 HCC44 C624(1.07)  LDD2171  [4]
 LDCM0369  CL100 PaTu 8988t C1261(0.70)  LDD1248  [4]
 LDCM0396  CL125 PaTu 8988t C1261(0.86)  LDD1275  [4]
 LDCM0397  CL126 PaTu 8988t C1261(0.83)  LDD1276  [4]
 LDCM0398  CL127 PaTu 8988t C1261(0.96)  LDD1277  [4]
 LDCM0399  CL128 PaTu 8988t C1261(1.03)  LDD1278  [4]
 LDCM0486  CL91 PaTu 8988t C1261(0.71)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C1261(0.53)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C1261(0.61)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C1261(0.41)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C1261(0.49)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C1261(0.44)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C1261(0.48)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C1261(0.60)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C1261(0.59)  LDD1373  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C305(0.88)  LDD1702  [5]
 LDCM0022  KB02 A-375 C1261(2.18)  LDD2255  [1]
 LDCM0023  KB03 A2780 C1261(2.04)  LDD2671  [1]
 LDCM0024  KB05 OAW-42 C1261(1.77)  LDD3369  [1]
 LDCM0021  THZ1 HCT 116 C624(1.07)  LDD2173  [4]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761