Details of the Target

General Information of Target

Target ID LDTP18436
Target Name Zinc finger protein 287 (ZNF287)
Gene Name ZNF287
Gene ID 57336
Synonyms
ZKSCAN13; Zinc finger protein 287; Zinc finger protein with KRAB and SCAN domains 13
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGFIFSKSMNESMKNQKEFMLMNARLQLERQLIMQSEMRERQMAMQIAWSREFLKYFGTF
FGLAAISLTAGAIKKKKPAFLVPIVPLSFILTYQYDLGYGTLLERMKGEAEDILETEKSK
LQLPRGMITFESIEKARKEQSRFFIDK
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9HBT7
Ensemble ID
ENST00000395824.5
HGNC ID
HGNC:13502

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C718(1.01)  LDD1509  [1]
N1
 Probe Info  		N.A.  LDD0245  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
HHS-465
 Probe Info  		Q443(0.00); H446(0.00); Q471(0.00); H474(0.00)  LDD2240  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C718(1.01)  LDD1509  [1]
 LDCM0259  AC14 HEK-293T C718(1.03)  LDD1512  [1]
 LDCM0278  AC19 HEK-293T C718(1.02)  LDD1517  [1]
 LDCM0282  AC22 HEK-293T C718(0.92)  LDD1521  [1]
 LDCM0287  AC27 HEK-293T C718(1.08)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C718(0.95)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C718(0.93)  LDD1530  [1]
 LDCM0296  AC35 HEK-293T C718(1.02)  LDD1535  [1]
 LDCM0299  AC38 HEK-293T C718(1.09)  LDD1538  [1]
 LDCM0305  AC43 HEK-293T C718(1.11)  LDD1544  [1]
 LDCM0308  AC46 HEK-293T C718(0.99)  LDD1547  [1]
 LDCM0314  AC51 HEK-293T C718(1.18)  LDD1553  [1]
 LDCM0317  AC54 HEK-293T C718(1.07)  LDD1556  [1]
 LDCM0322  AC59 HEK-293T C718(1.03)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C718(0.96)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C718(1.01)  LDD1565  [1]
 LDCM0368  CL10 HEK-293T C718(1.66)  LDD1572  [1]
 LDCM0406  CL19 HEK-293T C718(1.43)  LDD1610  [1]
 LDCM0410  CL22 HEK-293T C718(1.15)  LDD1614  [1]
 LDCM0420  CL31 HEK-293T C718(1.14)  LDD1624  [1]
 LDCM0423  CL34 HEK-293T C718(1.06)  LDD1627  [1]
 LDCM0433  CL43 HEK-293T C718(1.12)  LDD1637  [1]
 LDCM0436  CL46 HEK-293T C718(1.04)  LDD1640  [1]
 LDCM0446  CL55 HEK-293T C718(1.13)  LDD1649  [1]
 LDCM0449  CL58 HEK-293T C718(1.24)  LDD1652  [1]
 LDCM0459  CL67 HEK-293T C718(0.99)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C718(1.17)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C718(1.08)  LDD1666  [1]
 LDCM0472  CL79 HEK-293T C718(1.07)  LDD1675  [1]
 LDCM0476  CL82 HEK-293T C718(1.11)  LDD1679  [1]
 LDCM0486  CL91 HEK-293T C718(1.13)  LDD1689  [1]
 LDCM0489  CL94 HEK-293T C718(1.28)  LDD1692  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010