Details of the Target

General Information of Target

Target ID LDTP18361
Target Name Immortalization up-regulated protein (IMUP)
Gene Name IMUP
Gene ID 64073
Synonyms
C19orf33; Immortalization up-regulated protein; Hepatocyte growth factor activator inhibitor type 2-related small protein; H2RSP; HAI-2-related small protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMPSCNRSCSCSRGPSVEDGKWYGVRSYLHLFYEDCAGTALSDDPEGPPVLCPRRPWPSL
CWKISLSSGTLLLLLGVAALTTGYAVPPKLEGIGEGEFLVLDQRAADYNQALGTCRLAGT
ALCVAAGVLLAICLFWAMIGWLSQDTKAEPLDPEADSHVEVFGDEPEQQLSPIFRNASGQ
SWFSPPASPFGQSSVQTIQPKRDS
Target Bioclass
Other
Subcellular location
Nucleus
Uniprot ID
Q9GZP8
Ensemble ID
ENST00000301246.10
HGNC ID
HGNC:16668

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
Ishikawa (Heraklio) 02 ER SNV: p.D54G .
NCIH1155 SNV: p.M1? .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K32(5.88)  LDD0274  [1]
STPyne
 Probe Info  		K102(10.00); K32(9.95); K74(7.99)  LDD0277  [1]
m-APA
 Probe Info  		N.A.  LDD2233  [2]
IA-alkyne
 Probe Info  		C14(0.00); C639(0.00)  LDD0161  [3]
ATP probe
 Probe Info  		N.A.  LDD0035  [4]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096