Details of the Target

General Information of Target

Target ID LDTP18264
Target Name cTAGE family member 2 (CTAGE1)
Gene Name CTAGE1
Gene ID 64693
Synonyms
CTAGE2; cTAGE family member 2; Protein cTAGE-2; Cancer/testis antigen 21.2; CT21.2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPRCPPPCGCCERLVLNVAGLRFETRARTLGRFPDTLLGDPARRGRFYDDARREYFFDR
HRPSFDAVLYYYQSGGRLRRPAHVPLDVFLEEVAFYGLGAAALARLREDEGCPVPPERPL
PRRAFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVFCLETLPDFRDDRDGTGLAAA
AAAGPFPAPLNGSSQMPGNPPRLPFNDPFFVVETLCICWFSFELLVRLLVCPSKAIFFKN
VMNLIDFVAILPYFVALGTELARQRGVGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQI
LGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRVDSHFTSIPESFWWAVVTMTTVG
YGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFYHRETEGEEAGMFSHVDMQP
CGPLEGKANGGLVDGEVPELPPPLWAPPGKHLVTEV
Target Bioclass
Other
Family
CTAGE family
Subcellular location
Membrane
Uniprot ID
Q96RT6
Ensemble ID
ENST00000391403.4
HGNC ID
HGNC:24346

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL33 SNV: p.R522Q .
DU145 SNV: p.S343N .
HCT15 SNV: p.E172Ter .
HEC1 SNV: p.E629K .
HEC1B SNV: p.E629K .
HT115 SNV: p.I178M; p.F596C; p.L639I .
MCAS SNV: p.N450S .
MCC13 SNV: p.W182Ter .
NCIH1793 SNV: p.D259Y .
NCIH2172 SNV: p.P590Q .
RL952 SNV: p.K61E .
SKMEL30 SNV: p.E357K .
SW756 SNV: p.Ter746LextTer2 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C548(14.01)  LDD0204  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [2]
Acrolein
 Probe Info  		N.A.  LDD0217  [3]
Methacrolein
 Probe Info  		N.A.  LDD0218  [3]
W1
 Probe Info  		N.A.  LDD0236  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0102  BDHI 8 Jurkat C548(14.01)  LDD0204  [1]
 LDCM0109  NEM HeLa N.A.  LDD0224  [3]

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.