Details of the Target

General Information of Target

Target ID LDTP18220
Target Name Tetratricopeptide repeat protein 14 (TTC14)
Gene Name TTC14
Gene ID 151613
Synonyms
KIAA1980; Tetratricopeptide repeat protein 14; TPR repeat protein 14
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPLKFRDVAIEFSLEEWQCLDTIQQNLYRNVMLENYRNLVFLGIVVSKPDLITCLEQEK
EPWTRKRHRMVAEPPVICSHFAQDFSPEQNIKDSFQKVTPRRYGKCEHENLQLSKSVDEC
KVQKGGYNGLNQCLPTTQSKIFQCDKYMKIFHKFSNLNGHKVRHTRKKPFKYKEFGKSFC
IFSNLTQHKIICTRVNFYKCEDCGKAFNGSSIFTKHKRIHIGEKSYICEECGKACNQFTN
LTTHKIIYTRDKLYKREECSKAFNLSSHITTHTIIHTGENPYKREECDKAFNQSLTLTTH
KIIHTREKLNEYKECGKAFNQSSHLTRHKIIHTGEKPYKCEECGKAFNQSSHLTRHKIIH
TGEKPYRCEECGKAFRQSSHLTTHKIIHTGEKPYKCEECGKAFNKSSHLTRHKSIHTGEK
PYQCEKCGKASNQSSNLTEHKNIHTEEKPYKCEECGKAFNQFSNLTTHKRIHTGEKPYKC
EECGKAFNQSSILTTHKRIHTGEKSYKCEECGKAFYRSSKLTEHKKIHTGEKPYTCEECG
KAFNHSSHLATHKVIHTGEKPYQCEECGKAFNQSSHLTRHKRIHTGEKPYQCEKCGKAFN
QSSNLTGHKKIHTGEKLYKPKRCNSDFENTSKFSKHKRNYAGEKS
Target Bioclass
Other
Family
TTC14 family
Uniprot ID
Q96N46
Ensemble ID
ENST00000296015.9
HGNC ID
HGNC:24697

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.D178G .
AN3CA Deletion: p.E511VfsTer11 .
DU4475 SNV: p.R509C .
HCT116 SNV: p.R635M .
HEC1 SNV: p.K466N .
IM95 SNV: p.R32H .
JURKAT Deletion: p.K687NfsTer19 .
LNCaP clone FGC SNV: p.D529V .
MONOMAC6 SNV: p.F265L .
NCIH2172 SNV: p.E683K .
OVK18 SNV: p.A731E .
SNU1 SNV: p.I188N; p.I272M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C536(3.60)  LDD0171  [1]
DBIA
 Probe Info  		C634(1.12)  LDD0078  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C536(3.60)  LDD0171  [1]
 LDCM0281  AC21 HEK-293T C634(1.13)  LDD1520  [4]
 LDCM0289  AC29 HEK-293T C634(1.10)  LDD1528  [4]
 LDCM0298  AC37 HEK-293T C634(1.09)  LDD1537  [4]
 LDCM0307  AC45 HEK-293T C634(1.10)  LDD1546  [4]
 LDCM0312  AC5 HEK-293T C634(1.08)  LDD1551  [4]
 LDCM0316  AC53 HEK-293T C634(1.04)  LDD1555  [4]
 LDCM0325  AC61 HEK-293T C634(1.11)  LDD1564  [4]
 LDCM0248  AKOS034007472 HEK-293T C634(1.15)  LDD1511  [4]
 LDCM0020  ARS-1620 HCC44 C634(1.12)  LDD0078  [2]
 LDCM0367  CL1 HEK-293T C634(1.15)  LDD1571  [4]
 LDCM0370  CL101 HEK-293T C634(1.02)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C371(1.04)  LDD1575  [4]
 LDCM0374  CL105 HEK-293T C634(1.05)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C371(1.08)  LDD1579  [4]
 LDCM0378  CL109 HEK-293T C634(1.00)  LDD1582  [4]
 LDCM0380  CL110 HEK-293T C371(0.99)  LDD1584  [4]
 LDCM0383  CL113 HEK-293T C634(0.99)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C371(1.01)  LDD1588  [4]
 LDCM0387  CL117 HEK-293T C634(1.13)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C371(1.11)  LDD1592  [4]
 LDCM0392  CL121 HEK-293T C634(1.04)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C371(1.13)  LDD1597  [4]
 LDCM0396  CL125 HEK-293T C634(1.04)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C371(1.12)  LDD1601  [4]
 LDCM0400  CL13 HEK-293T C634(1.07)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C371(1.35)  LDD1605  [4]
 LDCM0407  CL2 HEK-293T C371(1.44)  LDD1611  [4]
 LDCM0409  CL21 HEK-293T C634(1.04)  LDD1613  [4]
 LDCM0413  CL25 HEK-293T C634(0.92)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C371(1.05)  LDD1618  [4]
 LDCM0422  CL33 HEK-293T C634(1.10)  LDD1626  [4]
 LDCM0426  CL37 HEK-293T C634(0.87)  LDD1630  [4]
 LDCM0435  CL45 HEK-293T C634(1.10)  LDD1639  [4]
 LDCM0439  CL49 HEK-293T C634(0.97)  LDD1643  [4]
 LDCM0441  CL50 HEK-293T C371(1.14)  LDD1645  [4]
 LDCM0448  CL57 HEK-293T C634(1.33)  LDD1651  [4]
 LDCM0453  CL61 HEK-293T C634(0.94)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C371(1.08)  LDD1657  [4]
 LDCM0461  CL69 HEK-293T C634(1.10)  LDD1664  [4]
 LDCM0466  CL73 HEK-293T C634(0.89)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C371(1.15)  LDD1670  [4]
 LDCM0475  CL81 HEK-293T C634(1.22)  LDD1678  [4]
 LDCM0479  CL85 HEK-293T C634(1.14)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C371(1.18)  LDD1683  [4]
 LDCM0484  CL9 HEK-293T C634(1.11)  LDD1687  [4]
 LDCM0488  CL93 HEK-293T C634(1.23)  LDD1691  [4]
 LDCM0492  CL97 HEK-293T C634(0.99)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C371(1.21)  LDD1696  [4]
 LDCM0427  Fragment51 HEK-293T C371(1.02)  LDD1631  [4]
 LDCM0022  KB02 HCT 116 C634(2.71)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C634(1.29)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C634(1.70)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C634(1.40)  LDD2173  [2]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402