Details of the Target

General Information of Target

Target ID LDTP18196
Target Name Mitochondrial inner membrane protease subunit 1 (IMMP1L)
Gene Name IMMP1L
Gene ID 196294
Synonyms
Mitochondrial inner membrane protease subunit 1; EC 3.4.21.-; IMP1-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLLDLMSSPSPQLLVAAAQQTLGMGKRRSPPQAICLHLAGEVLAVARGLKPAVLYDCNC
AGASELQSYLEELKGLGFLTFGLHILEIGENSLIVSPEHVCQHLEQVLLGTIAFVDVSSC
QRHPSVCSLDQLQDLKALVAEIITHLQGLQRDLSLAVSYSRLHSSDWNLCTVFGILLGYP
VPYTFHLNQGDDNCLALTPLRVFTARISWLLGQPPILLYSFSVPESLFPGLRDILNTWEK
DLRTRFRTQNDFADLSISSEIVTLPAVAL
Target Bioclass
Enzyme
Family
Peptidase S26 family, IMP1 subfamily
Subcellular location
Mitochondrion inner membrane
Function
Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
Uniprot ID
Q96LU5
Ensemble ID
ENST00000278200.5
HGNC ID
HGNC:26317

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C128(7.21)  LDD1706  [1]
DBIA
 Probe Info  		C128(1.10)  LDD1509  [2]
NAIA_5
 Probe Info  		N.A.  LDD2224  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C128(1.10)  LDD1509  [2]
 LDCM0259  AC14 HEK-293T C128(0.92)  LDD1512  [2]
 LDCM0278  AC19 HEK-293T C128(1.06)  LDD1517  [2]
 LDCM0282  AC22 HEK-293T C128(0.87)  LDD1521  [2]
 LDCM0287  AC27 HEK-293T C128(0.95)  LDD1526  [2]
 LDCM0290  AC3 HEK-293T C128(0.84)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C128(0.98)  LDD1530  [2]
 LDCM0296  AC35 HEK-293T C128(1.05)  LDD1535  [2]
 LDCM0299  AC38 HEK-293T C128(0.95)  LDD1538  [2]
 LDCM0305  AC43 HEK-293T C128(1.02)  LDD1544  [2]
 LDCM0308  AC46 HEK-293T C128(0.90)  LDD1547  [2]
 LDCM0314  AC51 HEK-293T C128(1.03)  LDD1553  [2]
 LDCM0317  AC54 HEK-293T C128(0.94)  LDD1556  [2]
 LDCM0322  AC59 HEK-293T C128(0.94)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C128(0.96)  LDD1562  [2]
 LDCM0326  AC62 HEK-293T C128(0.92)  LDD1565  [2]
 LDCM0367  CL1 HEK-293T C128(0.96)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C128(0.71)  LDD1572  [2]
 LDCM0370  CL101 HEK-293T C128(1.08)  LDD1574  [2]
 LDCM0374  CL105 HEK-293T C128(1.03)  LDD1578  [2]
 LDCM0378  CL109 HEK-293T C128(0.99)  LDD1582  [2]
 LDCM0383  CL113 HEK-293T C128(0.96)  LDD1587  [2]
 LDCM0387  CL117 HEK-293T C128(1.29)  LDD1591  [2]
 LDCM0392  CL121 HEK-293T C128(1.11)  LDD1596  [2]
 LDCM0396  CL125 HEK-293T C128(0.98)  LDD1600  [2]
 LDCM0400  CL13 HEK-293T C128(1.08)  LDD1604  [2]
 LDCM0406  CL19 HEK-293T C128(1.02)  LDD1610  [2]
 LDCM0410  CL22 HEK-293T C128(0.82)  LDD1614  [2]
 LDCM0413  CL25 HEK-293T C128(0.84)  LDD1617  [2]
 LDCM0420  CL31 HEK-293T C128(0.94)  LDD1624  [2]
 LDCM0423  CL34 HEK-293T C128(0.72)  LDD1627  [2]
 LDCM0426  CL37 HEK-293T C128(0.96)  LDD1630  [2]
 LDCM0433  CL43 HEK-293T C128(0.96)  LDD1637  [2]
 LDCM0436  CL46 HEK-293T C128(0.68)  LDD1640  [2]
 LDCM0439  CL49 HEK-293T C128(0.68)  LDD1643  [2]
 LDCM0446  CL55 HEK-293T C128(1.13)  LDD1649  [2]
 LDCM0449  CL58 HEK-293T C128(0.71)  LDD1652  [2]
 LDCM0453  CL61 HEK-293T C128(0.97)  LDD1656  [2]
 LDCM0459  CL67 HEK-293T C128(0.89)  LDD1662  [2]
 LDCM0462  CL7 HEK-293T C128(0.84)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C128(0.81)  LDD1666  [2]
 LDCM0466  CL73 HEK-293T C128(1.18)  LDD1669  [2]
 LDCM0472  CL79 HEK-293T C128(0.95)  LDD1675  [2]
 LDCM0476  CL82 HEK-293T C128(0.86)  LDD1679  [2]
 LDCM0479  CL85 HEK-293T C128(1.03)  LDD1682  [2]
 LDCM0486  CL91 HEK-293T C128(1.14)  LDD1689  [2]
 LDCM0489  CL94 HEK-293T C128(0.77)  LDD1692  [2]
 LDCM0492  CL97 HEK-293T C128(1.22)  LDD1695  [2]
 LDCM0024  KB05 T cell-activated C128(7.21)  LDD1706  [1]

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264