Details of the Target

General Information of Target

Target ID LDTP18112
Target Name Protein LZIC (LZIC)
Gene Name LZIC
Gene ID 84328
Synonyms
Protein LZIC; Leucine zipper and CTNNBIP1 domain-containing protein; Leucine zipper and ICAT homologous domain-containing protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNSLKDGNHTALTGFILLGLTDDPILRVILFMIILSGNLSIIILIRISSQLHHPMYFFLS
HLAFADMAYSSSVTPNMLVNFLVERNTVSYLGCAIQLGSAAFFATVECVLLAAMAYDRFV
AICSPLLYSTKMSTQVSVQLLLVVYIAGFLIAVSYTTSFYFLLFCGPNQVNHFFCDFAPL
LELSCSDISVSTVVLSFSSGSIIVVTVCVIAVCYIYILITILKMRSTEGHHKAFSTCTSH
LTVVTLFYGTITFIYVMPNFSYSTDQNKVVSVLYTVVIPMLNPLIYSLRNKEIKGALKRE
LVRKILSHDACYFSRTSNNDIT
Target Bioclass
Other
Family
CTNNBIP1 family
Uniprot ID
Q8WZA0
Ensemble ID
ENST00000377213.1
HGNC ID
HGNC:17497
ChEMBL ID
CHEMBL4296296

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.T39A .
JURKAT SNV: p.A157T .
MOLT4 SNV: p.L16S .
SW756 SNV: p.S154Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C33(0.88)  LDD1492  [1]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [2]
Acrolein
 Probe Info  		N.A.  LDD0217  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C33(1.13)  LDD1508  [1]
 LDCM0237  AC12 HEK-293T C33(0.79)  LDD1510  [1]
 LDCM0277  AC18 HEK-293T C33(1.05)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C33(1.06)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C33(0.77)  LDD1519  [1]
 LDCM0286  AC26 HEK-293T C33(0.97)  LDD1525  [1]
 LDCM0288  AC28 HEK-293T C33(0.76)  LDD1527  [1]
 LDCM0295  AC34 HEK-293T C33(1.03)  LDD1534  [1]
 LDCM0297  AC36 HEK-293T C33(0.93)  LDD1536  [1]
 LDCM0301  AC4 HEK-293T C33(0.86)  LDD1540  [1]
 LDCM0304  AC42 HEK-293T C33(1.23)  LDD1543  [1]
 LDCM0306  AC44 HEK-293T C33(0.87)  LDD1545  [1]
 LDCM0313  AC50 HEK-293T C33(1.17)  LDD1552  [1]
 LDCM0315  AC52 HEK-293T C33(0.90)  LDD1554  [1]
 LDCM0321  AC58 HEK-293T C33(1.15)  LDD1560  [1]
 LDCM0324  AC60 HEK-293T C33(0.90)  LDD1563  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0367  CL1 HEK-293T C33(1.04)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C33(0.93)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C33(0.88)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C33(0.94)  LDD1576  [1]
 LDCM0374  CL105 HEK-293T C33(1.02)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C33(0.80)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C33(1.04)  LDD1580  [1]
 LDCM0378  CL109 HEK-293T C33(1.03)  LDD1582  [1]
 LDCM0380  CL110 HEK-293T C33(0.75)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C33(0.94)  LDD1585  [1]
 LDCM0383  CL113 HEK-293T C33(1.01)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C33(0.73)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C33(1.03)  LDD1589  [1]
 LDCM0387  CL117 HEK-293T C33(0.94)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C33(0.95)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C33(1.03)  LDD1593  [1]
 LDCM0392  CL121 HEK-293T C33(0.99)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C33(0.95)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C33(1.00)  LDD1598  [1]
 LDCM0396  CL125 HEK-293T C33(0.93)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C33(0.79)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C33(0.95)  LDD1602  [1]
 LDCM0400  CL13 HEK-293T C33(1.04)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C33(0.78)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C33(1.03)  LDD1606  [1]
 LDCM0405  CL18 HEK-293T C33(1.08)  LDD1609  [1]
 LDCM0407  CL2 HEK-293T C33(0.96)  LDD1611  [1]
 LDCM0408  CL20 HEK-293T C33(1.04)  LDD1612  [1]
 LDCM0413  CL25 HEK-293T C33(1.03)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C33(0.92)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C33(0.98)  LDD1619  [1]
 LDCM0418  CL3 HEK-293T C33(0.87)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C33(1.42)  LDD1623  [1]
 LDCM0421  CL32 HEK-293T C33(0.96)  LDD1625  [1]
 LDCM0426  CL37 HEK-293T C33(1.00)  LDD1630  [1]
 LDCM0428  CL39 HEK-293T C33(0.82)  LDD1632  [1]
 LDCM0432  CL42 HEK-293T C33(1.23)  LDD1636  [1]
 LDCM0434  CL44 HEK-293T C33(0.83)  LDD1638  [1]
 LDCM0439  CL49 HEK-293T C33(1.03)  LDD1643  [1]
 LDCM0441  CL50 HEK-293T C33(0.75)  LDD1645  [1]
 LDCM0445  CL54 HEK-293T C33(1.17)  LDD1648  [1]
 LDCM0447  CL56 HEK-293T C33(1.12)  LDD1650  [1]
 LDCM0451  CL6 HEK-293T C33(1.34)  LDD1654  [1]
 LDCM0453  CL61 HEK-293T C33(1.13)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C33(0.97)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C33(1.03)  LDD1658  [1]
 LDCM0458  CL66 HEK-293T C33(1.25)  LDD1661  [1]
 LDCM0460  CL68 HEK-293T C33(1.01)  LDD1663  [1]
 LDCM0466  CL73 HEK-293T C33(1.10)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C33(0.88)  LDD1670  [1]
 LDCM0471  CL78 HEK-293T C33(1.09)  LDD1674  [1]
 LDCM0473  CL8 HEK-293T C33(0.75)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C33(1.03)  LDD1677  [1]
 LDCM0479  CL85 HEK-293T C33(1.11)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C33(0.98)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C33(1.03)  LDD1684  [1]
 LDCM0485  CL90 HEK-293T C33(1.09)  LDD1688  [1]
 LDCM0487  CL92 HEK-293T C33(0.84)  LDD1690  [1]
 LDCM0492  CL97 HEK-293T C33(0.88)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C33(0.81)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C33(1.05)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C33(1.15)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C33(1.04)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C33(0.95)  LDD1631  [1]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0022  KB02 HEK-293T C33(0.88)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C33(0.98)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C33(0.89)  LDD1502  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 558 (ZNF558) Krueppel C2H2-type zinc-finger protein family Q96NG5

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.