Details of the Target

General Information of Target

Target ID LDTP18043
Target Name Zinc finger protein 563 (ZNF563)
Gene Name ZNF563
Gene ID 147837
Synonyms
Zinc finger protein 563
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKFRAKITGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCFGPAGSGGLHEARLWCEVRQ
GAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSAAGASSLKLQLTHKRRPSLTVAVELVS
SLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLRSIVERMANVGSHVL
VEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPENRDLESMVQVRVDNRKLLQFL
EGQQIHPTTALCNIWDNTLLQLVLVQEDVSLQYFIPAL
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q8TA94
Ensemble ID
ENST00000293725.10
HGNC ID
HGNC:30498

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 SNV: p.K172N .
HCC70 SNV: p.I91M .
KYSE30 SNV: p.T83S .
MCC13 SNV: p.S239F .
MDST8 SNV: p.H128Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C227(2.31)  LDD0170  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C227(2.31)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C227(2.25)  LDD0171  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 10-6 (KRTAP10-6) KRTAP type 10 family P60371

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625