Details of the Target

General Information of Target

Target ID LDTP18040
Target Name Putative ribosomal protein uL10-like (RPLP0P6)
Gene Name RPLP0P6
Synonyms
Putative ribosomal protein uL10-like; 60S acidic ribosomal protein P0-like; Large ribosomal subunit protein uL10-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDKLTIISGCLFLAADIFAIASIANPDWINTGESAGALTVGLVRQCQTIHGRDRTCIPPR
LPPEWVTTLFFIIMGIISLTVTCGLLVASHWRREATKYARWIAFTGMILFCMAALIFPIG
FYINEVGGQPYKLPNNTVVGSSYVLFVLSIFFTIVGLLFAGKVCLPG
Target Bioclass
Other
Family
Universal ribosomal protein uL10 family
Function Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
Uniprot ID
Q8NHW5
HGNC ID
HGNC:36404

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
AZ-9
 Probe Info  		E70(1.24); D23(1.02)  LDD2208  [2]
IPM
 Probe Info  		C119(0.00); C27(0.00)  LDD0241  [3]
DBIA
 Probe Info  		C27(5.04)  LDD3312  [4]
AHL-Pu-1
 Probe Info  		C119(3.08)  LDD0170  [5]
Ox-W18
 Probe Info  		N.A.  LDD2175  [6]
W1
 Probe Info  		N.A.  LDD0236  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C119(3.08)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C119(3.81)  LDD0171  [5]
 LDCM0020  ARS-1620 HCC44 C27(1.11); C119(1.02)  LDD2171  [7]
 LDCM0022  KB02 22RV1 C27(3.58)  LDD2243  [4]
 LDCM0023  KB03 22RV1 C27(7.70)  LDD2660  [4]
 LDCM0024  KB05 HMCB C27(5.04)  LDD3312  [4]
 LDCM0021  THZ1 HCT 116 C27(1.11); C119(1.02)  LDD2173  [7]

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.