Details of the Target

General Information of Target

Target ID LDTP18039
Target Name Modulator of smoothened protein (MOSMO)
Gene Name MOSMO
Gene ID 730094
Synonyms
ATTHOG; C16orf52; Modulator of smoothened protein; Attenuator of hedgehog
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTDKTEKVAVDPETVFKRPRECDSPSYQKRQRMALLARKQGAGDSLIAGSAMSKEKKLMT
GHAIPPSQLDSQIDDFTGFSKDRMMQKPGSNAPVGGNVTSSFSGDDLECRETASSPKSQR
EINADIKRKLVKELRCVGQKYEKIFEMLEGVQGPTAVRKRFFESIIKEAARCMRRDFVKH
LKKKLKRMI
Target Bioclass
Other
Subcellular location
Cell projection, cilium membrane
Function
Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane. Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation.
Uniprot ID
Q8NHV5
Ensemble ID
ENST00000331057.8
HGNC ID
HGNC:27087

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
SUPT1 Deletion: p.F71LfsTer9 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C46(1.60)  LDD3413  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C46(1.15)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C46(0.95)  LDD1508  [2]
 LDCM0259  AC14 HEK-293T C46(0.86)  LDD1512  [2]
 LDCM0276  AC17 HEK-293T C46(1.08)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C46(1.00)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C46(1.11)  LDD1518  [2]
 LDCM0282  AC22 HEK-293T C46(0.91)  LDD1521  [2]
 LDCM0285  AC25 HEK-293T C46(0.98)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C46(0.99)  LDD1525  [2]
 LDCM0291  AC30 HEK-293T C46(0.85)  LDD1530  [2]
 LDCM0294  AC33 HEK-293T C46(1.11)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C46(1.10)  LDD1534  [2]
 LDCM0299  AC38 HEK-293T C46(0.95)  LDD1538  [2]
 LDCM0303  AC41 HEK-293T C46(1.29)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C46(1.17)  LDD1543  [2]
 LDCM0308  AC46 HEK-293T C46(0.85)  LDD1547  [2]
 LDCM0311  AC49 HEK-293T C46(1.16)  LDD1550  [2]
 LDCM0313  AC50 HEK-293T C46(1.12)  LDD1552  [2]
 LDCM0317  AC54 HEK-293T C46(1.06)  LDD1556  [2]
 LDCM0320  AC57 HEK-293T C46(1.04)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C46(1.04)  LDD1560  [2]
 LDCM0323  AC6 HEK-293T C46(0.82)  LDD1562  [2]
 LDCM0326  AC62 HEK-293T C46(0.93)  LDD1565  [2]
 LDCM0356  AKOS034007680 HEK-293T C46(1.39)  LDD1570  [2]
 LDCM0368  CL10 HEK-293T C46(0.84)  LDD1572  [2]
 LDCM0404  CL17 HEK-293T C46(1.20)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C46(1.01)  LDD1609  [2]
 LDCM0410  CL22 HEK-293T C46(1.03)  LDD1614  [2]
 LDCM0417  CL29 HEK-293T C46(1.03)  LDD1621  [2]
 LDCM0419  CL30 HEK-293T C46(1.07)  LDD1623  [2]
 LDCM0423  CL34 HEK-293T C46(1.06)  LDD1627  [2]
 LDCM0431  CL41 HEK-293T C46(1.16)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C46(1.07)  LDD1636  [2]
 LDCM0436  CL46 HEK-293T C46(0.92)  LDD1640  [2]
 LDCM0440  CL5 HEK-293T C46(1.15)  LDD1644  [2]
 LDCM0444  CL53 HEK-293T C46(1.01)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C46(1.06)  LDD1648  [2]
 LDCM0449  CL58 HEK-293T C46(0.98)  LDD1652  [2]
 LDCM0451  CL6 HEK-293T C46(1.07)  LDD1654  [2]
 LDCM0457  CL65 HEK-293T C46(1.11)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C46(1.05)  LDD1661  [2]
 LDCM0463  CL70 HEK-293T C46(1.02)  LDD1666  [2]
 LDCM0470  CL77 HEK-293T C46(1.05)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C46(1.16)  LDD1674  [2]
 LDCM0476  CL82 HEK-293T C46(0.89)  LDD1679  [2]
 LDCM0483  CL89 HEK-293T C46(1.18)  LDD1686  [2]
 LDCM0485  CL90 HEK-293T C46(1.06)  LDD1688  [2]
 LDCM0489  CL94 HEK-293T C46(0.86)  LDD1692  [2]
 LDCM0022  KB02 A2058 C46(1.82)  LDD2253  [1]
 LDCM0023  KB03 COLO-679 C46(1.99)  LDD2722  [1]
 LDCM0024  KB05 RVH-421 C46(1.60)  LDD3413  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402