Details of the Target
General Information of Target
| Target ID | LDTP17767 | |||||
|---|---|---|---|---|---|---|
| Target Name | Protein TOPAZ1 (TOPAZ1) | |||||
| Gene Name | TOPAZ1 | |||||
| Gene ID | 375337 | |||||
| Synonyms |
C3orf77; Protein TOPAZ1; Testis- and ovary-specific PAZ domain-containing protein 1 |
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| 3D Structure | ||||||
| Sequence |
MATEFIKSCCGGCFYGETEKHNFSVERDFKAAVPNSQNATISVPPLTSVSVKPQLGCTED
YLLSKLPSDGKEVPFVVPKFKLSYIQPRTQETPSHLEELEGSARASFGDRKVELSSSSQH GPSYDVYNPFYMYQHISPDLSRRFPPRSEVKRLYGSVCDLRTNKLPGSPGLSKSMFDLTN SSQRFIQRHDSLSSVPSSSSSRKNSQGSNRSLDTITLSGDERDFGRLNVKLFYNSSVEQI WITVLQCRDLSWPSSYGDTPTVSIKGILTLPKPVHFKSSAKEGSNAIEFMETFVFAIKLQ NLQTVRLVFKIQTQTPRKKTIGECSMSLRTLSTQEMDYSLDITPPSKISVCHAELELGTC FQAVNSRIQLQILEARYLPSSSTPLTLSFFVKVGMFSSGELIYKKKTRLLKASNGRVKWG ETMIFPLIQSEKEIVFLIKLYSRSSVRRKHFVGQIWISEDSNNIEAVNQWKETVINPEKV VIRWHKLNPS |
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| Target Bioclass |
Other
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| Subcellular location |
Cytoplasm, cytosol
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| Function |
Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
Acrolein Probe Info |
 |
C311(0.00); H314(0.00) | LDD0231 | [1] | |
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W1 Probe Info |
 |
E1292(0.91) | LDD0239 | [2] | |
Competitor(s) Related to This Target
References