Details of the Target

General Information of Target

Target ID LDTP17731
Target Name Protein NATD1 (NATD1)
Gene Name NATD1
Gene ID 256302
Synonyms
C17orf103; GTLF3B; Protein NATD1; N-acetyltransferase domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAEEKDPLSYFAAYGSSSSGSSDEEDNIEPEETSRRTPDPAKSAGGCRNKAEKRLPGPD
ELFRSVTRPAFLYNPLNKQIDWERHVVKAPEEPPKEFKIWKSNYVPPPETYTTEKKPPPP
ELDMAIKWSNIYEDNGDDAPQNAKKARLLPEGEETLESDDEKDEHTSKKRKVEPGEPAKK
KK
Target Bioclass
Other
Family
NATD1 family
Uniprot ID
Q8N6N6
Ensemble ID
ENST00000611551.1
HGNC ID
HGNC:30770

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K71(4.71)  LDD0277  [1]
DBIA
 Probe Info  		C92(1.09)  LDD0080  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
NAIA_5
 Probe Info  		N.A.  LDD2225  [4]
ENE
 Probe Info  		N.A.  LDD0006  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
VSF
 Probe Info  		N.A.  LDD0007  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C37(1.01)  LDD1510  [8]
 LDCM0280  AC20 HEK-293T C37(1.02)  LDD1519  [8]
 LDCM0288  AC28 HEK-293T C37(1.02)  LDD1527  [8]
 LDCM0297  AC36 HEK-293T C37(0.98)  LDD1536  [8]
 LDCM0301  AC4 HEK-293T C37(1.00)  LDD1540  [8]
 LDCM0306  AC44 HEK-293T C37(1.03)  LDD1545  [8]
 LDCM0315  AC52 HEK-293T C37(1.08)  LDD1554  [8]
 LDCM0324  AC60 HEK-293T C37(1.03)  LDD1563  [8]
 LDCM0372  CL103 HEK-293T C37(0.77)  LDD1576  [8]
 LDCM0376  CL107 HEK-293T C37(0.73)  LDD1580  [8]
 LDCM0381  CL111 HEK-293T C37(0.82)  LDD1585  [8]
 LDCM0385  CL115 HEK-293T C37(0.85)  LDD1589  [8]
 LDCM0389  CL119 HEK-293T C37(0.78)  LDD1593  [8]
 LDCM0394  CL123 HEK-293T C37(0.75)  LDD1598  [8]
 LDCM0398  CL127 HEK-293T C37(1.10)  LDD1602  [8]
 LDCM0402  CL15 HEK-293T C37(0.83)  LDD1606  [8]
 LDCM0408  CL20 HEK-293T C37(0.97)  LDD1612  [8]
 LDCM0415  CL27 HEK-293T C37(0.81)  LDD1619  [8]
 LDCM0418  CL3 HEK-293T C37(1.03)  LDD1622  [8]
 LDCM0421  CL32 HEK-293T C37(0.95)  LDD1625  [8]
 LDCM0428  CL39 HEK-293T C37(0.85)  LDD1632  [8]
 LDCM0434  CL44 HEK-293T C37(0.98)  LDD1638  [8]
 LDCM0447  CL56 HEK-293T C37(1.03)  LDD1650  [8]
 LDCM0455  CL63 HEK-293T C37(0.85)  LDD1658  [8]
 LDCM0460  CL68 HEK-293T C37(1.01)  LDD1663  [8]
 LDCM0473  CL8 HEK-293T C37(0.89)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C37(0.97)  LDD1677  [8]
 LDCM0481  CL87 HEK-293T C37(1.23)  LDD1684  [8]
 LDCM0487  CL92 HEK-293T C37(1.09)  LDD1690  [8]
 LDCM0494  CL99 HEK-293T C37(1.05)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C37(0.86)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C37(0.85)  LDD1671  [8]
 LDCM0022  KB02 HCT 116 C92(1.09)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C92(1.43)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C92(1.28)  LDD0082  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C17(0.57)  LDD2207  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein 426 (ZNF426) . Q9BUY5
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein INCA1 (INCA1) INCA family Q0VD86
PRKCA-binding protein (PICK1) . Q9NRD5
Puratrophin-1 (PLEKHG4) . Q58EX7

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.