Details of the Target

General Information of Target

Target ID LDTP17647
Target Name Zinc finger protein 595 (ZNF595)
Gene Name ZNF595
Gene ID 152687
Synonyms
Zinc finger protein 595
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNTIVFNKLSGAVLFEDGGASERERGGRPYSGVLDSPHARPEVGIPDGPPLKDNLGLRHR
RTGARQNGGKVRHKRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGSQMTLVQVSNW
FANARRRLKNTVRQPDLSWALRIKLYNKYVQGNAERLSVSSDDSCSEDGENPPRTHMNEG
GYNTPVHHPVIKSENSVIKAGVRPESRASEDYVAPPKYKSSLLNRYLNDSLRHVMATNTT
MMGKTRQRNHSGSFSSNEFEEELVSPSSSETEGNFVYRTDTLENGSNKGESAANRKGPSK
DDTYWKEINAAMALTNLAQGKDKLQGTTSCIIQKSSHIAEVKTVKVPLVQQF
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q8IYB9
Ensemble ID
ENST00000610261.6
HGNC ID
HGNC:27196

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C20(1.28); C55(1.07)  LDD3340  [1]
IA-alkyne
 Probe Info  		C55(0.00); C63(0.00)  LDD0149  [2]
HHS-465
 Probe Info  		K254(0.00); K257(0.00); Y256(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C20(1.08)  LDD1512  [4]
 LDCM0282  AC22 HEK-293T C20(0.78)  LDD1521  [4]
 LDCM0291  AC30 HEK-293T C20(1.10)  LDD1530  [4]
 LDCM0299  AC38 HEK-293T C20(0.98)  LDD1538  [4]
 LDCM0308  AC46 HEK-293T C20(1.10)  LDD1547  [4]
 LDCM0317  AC54 HEK-293T C20(1.23)  LDD1556  [4]
 LDCM0323  AC6 HEK-293T C20(0.92)  LDD1562  [4]
 LDCM0326  AC62 HEK-293T C20(1.08)  LDD1565  [4]
 LDCM0368  CL10 HEK-293T C20(1.34)  LDD1572  [4]
 LDCM0410  CL22 HEK-293T C20(1.08)  LDD1614  [4]
 LDCM0423  CL34 HEK-293T C20(1.17)  LDD1627  [4]
 LDCM0436  CL46 HEK-293T C20(1.37)  LDD1640  [4]
 LDCM0449  CL58 HEK-293T C20(1.37)  LDD1652  [4]
 LDCM0463  CL70 HEK-293T C20(1.32)  LDD1666  [4]
 LDCM0476  CL82 HEK-293T C20(1.46)  LDD1679  [4]
 LDCM0489  CL94 HEK-293T C20(1.17)  LDD1692  [4]
 LDCM0022  KB02 22RV1 C55(1.34)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C55(2.57)  LDD2660  [1]
 LDCM0024  KB05 NB1 C20(1.28); C55(1.07)  LDD3340  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 10-6 (KRTAP10-6) KRTAP type 10 family P60371

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402