Details of the Target

General Information of Target

Target ID	LDTP17542
Target Name	Protein FAM220A (FAM220A)
Gene Name	FAM220A
Gene ID	84792
Synonyms	C7orf70; SIPAR; Protein FAM220A; STAT3-interacting protein as a repressor
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MEDEEVAESWEEAADSGEIDRRLEKKLKITQKESRKSKSPPKVPIVIQDDSLPAGPPPQI RILKRPTSNGVVSSPNSTSRPTLPVKSLAQREAEYAEARKRILGSASPEEEQEKPILDRP TRISQPEDSRQPNNVIRQPLGPDGSQGFKQRR
Target Bioclass	Other
Subcellular location	Nucleus
Function	May negatively regulate STAT3.
Uniprot ID	Q7Z4H9
Ensemble ID	ENST00000313324.9
HGNC ID	HGNC:22422

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
CY4 Probe Info			N.A.	LDD0247	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Tektin-4 (TEKT4)				Tektin family	Q8WW24

References

1	Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.