Details of the Target

General Information of Target

Target ID LDTP17534
Target Name Probable C-mannosyltransferase DPY19L4 (DPY19L4)
Gene Name DPY19L4
Gene ID 286148
Synonyms
Probable C-mannosyltransferase DPY19L4; EC 2.4.1.-; Dpy-19-like protein 4; Protein dpy-19 homolog 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQEKMELDLEPDTSYGGTLRRSSSAPLIHGLSDLSQVFQPYTLRTRRNSTTIMSRHSLE
EGLDMVNRETAHEREMQTAMQISQSWDESLSLSDSDFDKPEKLYSPKRIDFTPVSPAPSP
TRGFGKMFVSSSGLPPSPVPSPRRFSRRSQSPVKCIRPSVLGPLKRKGEMETESQPKRLF
QGTTNMLSPDAAQLSDLSSCSDILDGSSSSSGLSSDPLAKGSATAESPVACSNSCSSFIL
MDDLSPK
Target Bioclass
Enzyme
Family
Dpy-19 family
Subcellular location
Membrane
Function Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.
Uniprot ID
Q7Z388
Ensemble ID
ENST00000414645.6
HGNC ID
HGNC:27829

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C672(0.93)  LDD1573  [1]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OEA-DA
 Probe Info  		20.00  LDD0046  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0369  CL100 HEK-293T C672(0.93)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C672(1.04)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C672(0.99)  LDD1581  [1]
 LDCM0382  CL112 HEK-293T C672(1.03)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C672(1.08)  LDD1590  [1]
 LDCM0391  CL120 HEK-293T C672(1.13)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C672(0.97)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C672(1.13)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C672(1.23)  LDD1607  [1]
 LDCM0416  CL28 HEK-293T C672(0.96)  LDD1620  [1]
 LDCM0429  CL4 HEK-293T C672(1.07)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C672(1.14)  LDD1634  [1]
 LDCM0443  CL52 HEK-293T C672(1.14)  LDD1646  [1]
 LDCM0456  CL64 HEK-293T C672(1.11)  LDD1659  [1]
 LDCM0469  CL76 HEK-293T C672(1.00)  LDD1672  [1]
 LDCM0482  CL88 HEK-293T C672(1.32)  LDD1685  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570