Details of the Target

General Information of Target

Target ID LDTP17499
Target Name Coiled-coil domain-containing protein 9B (CCDC9B)
Gene Name CCDC9B
Gene ID 388115
Synonyms
C15orf52; Coiled-coil domain-containing protein 9B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQR
LGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASV
DELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYLQERLKQLHEEVN
LLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQSISD
LKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILF
SDPTLPSGQRSRSPLLKFVEQPTENKADPKDGEAQKQEEDESCAAAEALTAPEDAGRPAV
NSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIEGQR
SETGPAPPGLAIQGELPKSHLDSFEASRPAAKASTPEDGKGIPEGGGMRSTVKT
Target Bioclass
Other
Uniprot ID
Q6ZUT6
Ensemble ID
ENST00000397536.7
HGNC ID
HGNC:33488

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.75  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
BTD
 Probe Info  		C276(0.79)  LDD2137  [3]
AHL-Pu-1
 Probe Info  		C475(3.11); C410(2.16)  LDD0170  [4]
DBIA
 Probe Info  		C276(0.90)  LDD0078  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [6]
IPM
 Probe Info  		N.A.  LDD0025  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C475(3.11); C410(2.16)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C475(4.44); C437(19.11); C276(2.69); C157(3.50)  LDD0171  [4]
 LDCM0020  ARS-1620 HCC44 C276(0.90)  LDD0078  [5]
 LDCM0630  CCW28-3 231MFP C437(1.20)  LDD2214  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C276(1.44)  LDD1702  [3]
 LDCM0022  KB02 8305C C410(1.24)  LDD2248  [10]
 LDCM0023  KB03 MDA-MB-231 C276(1.76)  LDD1701  [3]
 LDCM0024  KB05 OCUG-1 C437(2.19)  LDD3373  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C276(0.79)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C276(0.94)  LDD2140  [3]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840