Details of the Target

General Information of Target

Target ID LDTP17396
Target Name POM121 and ZP3 fusion protein (POMZP3)
Gene Name POMZP3
Gene ID 22932
Synonyms
POM121 and ZP3 fusion protein; POM-ZP3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDRGSLLPFQLWCPRPFGTYSQNQPRPPSAALKPSACPEPGGGAEPDHGPAHSENTPPAL
ATEVPASQPAPLLSAAAAGDEGRVLLDTWYVIKPGNTKEKVAFFVAHQCGGGSRASSMKV
KGHWGSDSSKAKRRRRCLDPTKAPPDPGGREGPPAAEEGPASAGEDVDLLSVAEMVALVE
QRAALALQSYPRPTTPAPVVFVSAEQGGPAKGVGSERRSGGGDCSRVAEAVAHFEAQRDS
PPTKGLRKEERPGPGPGEVRIAFRISNGREPRAPDSGLPSGGGGRPGCAYPGSPGPGARA
KDKITCDLYQLISPSRDALPSNVEFLLARADEASEGDSPAPARPEDTPPAPPPPPARDCG
ASGFHVDVVVTGVVDECIFFGKDGTKNVKEETVCLTVSPEEPPPPGQLFFLQNRGPDGPP
EPPPADSPATAPGPDDAEGTADTSLCRLYRHVSHDFLEIRFKIQRLLEPRQYMLLLPEHV
LVKIFSFLPTRALAALKCTCHHFKGIIEAFGVRATDSRWSRDPLYRDDPCKQCRKRYEKG
DVSLCRWHPKPYHHDLPYGRSYWMCCRRADRETPGCRLGLHDNNWVLPCNGPGGGRAGRE
EGR
Target Bioclass
Other
Uniprot ID
Q6PJE2
Ensemble ID
ENST00000275569.8
HGNC ID
HGNC:9203

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C3(3.23)  LDD1702  [1]
DBIA
 Probe Info  		C3(1.02)  LDD1512  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C3(1.02)  LDD1512  [2]
 LDCM0282  AC22 HEK-293T C3(0.88)  LDD1521  [2]
 LDCM0291  AC30 HEK-293T C3(0.87)  LDD1530  [2]
 LDCM0299  AC38 HEK-293T C3(0.94)  LDD1538  [2]
 LDCM0308  AC46 HEK-293T C3(1.00)  LDD1547  [2]
 LDCM0317  AC54 HEK-293T C3(1.02)  LDD1556  [2]
 LDCM0323  AC6 HEK-293T C3(1.17)  LDD1562  [2]
 LDCM0326  AC62 HEK-293T C3(1.05)  LDD1565  [2]
 LDCM0368  CL10 HEK-293T C3(1.29)  LDD1572  [2]
 LDCM0410  CL22 HEK-293T C3(1.25)  LDD1614  [2]
 LDCM0423  CL34 HEK-293T C3(1.16)  LDD1627  [2]
 LDCM0436  CL46 HEK-293T C3(1.29)  LDD1640  [2]
 LDCM0449  CL58 HEK-293T C3(1.35)  LDD1652  [2]
 LDCM0463  CL70 HEK-293T C3(1.12)  LDD1666  [2]
 LDCM0476  CL82 HEK-293T C3(0.91)  LDD1679  [2]
 LDCM0489  CL94 HEK-293T C3(1.08)  LDD1692  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C3(3.23)  LDD1702  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264